Table of Contents Author Guidelines Submit a Manuscript
Journal of Diabetes Research
Volume 2015, Article ID 965056, 9 pages
http://dx.doi.org/10.1155/2015/965056
Research Article

Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice

1Université Paris Descartes, 75014 Paris, France
2CNRS UMR 8147, Hôpital Necker, 75015 Paris, France
3CNRS UMR 8104, Cochin Institute, 75014 Paris, France
4INSERM U1016, Cochin Institute, 75014 Paris, France
5Center of Excellence, LABEX Inflamex, 75014 Paris, France

Received 7 January 2015; Revised 13 April 2015; Accepted 15 April 2015

Academic Editor: Mark A. Yorek

Copyright © 2015 Manal Alkan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Stegaev, A. T. Nies, P. Porola et al., “Histamine transport and metabolism are deranged in salivary glands in Sjögren's syndrome,” Rheumatology, vol. 52, no. 9, Article ID ket188, pp. 1599–1608, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. D. B. Frewin, L. G. Cleland, J. R. Jonsson, and P. W. Robertson, “Histamine levels in human synovial fluid,” The Journal of Rheumatology, vol. 13, no. 1, pp. 13–14, 1986. View at Google Scholar · View at Scopus
  3. D. S. Gill, M. A. Barradas, V. A. Fonseca, and P. Dandona, “Plasma histamine concentrations are elevated in patients with diabetes mellitus and peripheral vascular diasease,” Metabolism, vol. 38, no. 3, pp. 243–247, 1989. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Tuomisto, H. Kilpeläinen, and P. Riekkinen, “Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis,” Agents and Actions, vol. 13, no. 2-3, pp. 255–257, 1983. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Raithel, M. Matek, H. W. Baenkler, W. Jorde, and E. G. Hahn, “Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy,” International Archives of Allergy and Immunology, vol. 108, no. 2, pp. 127–133, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. H. W. Baenkler, G. Lux, R. Gunthner, M. Kohlhaufl, and W. Matek, “Biopsy histamine in ulcerative colitis and Crohn's disease,” Hepato-Gastroenterology, vol. 34, no. 6, pp. 289–290, 1987. View at Google Scholar · View at Scopus
  7. E. Schneider, M. Rolli-Derkinderen, M. Arock, and M. Dy, “Trends in histamine research: new functions during immune responses and hematopoiesis,” Trends in Immunology, vol. 23, no. 5, pp. 255–263, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. K.-Y. Wang, A. Tanimoto, X. Guo et al., “Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 4, pp. 800–807, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Inui, R. Yasuno, M. Takenoshita et al., “Increases in gastric histidine decarboxylase activity and plasma gastrin level in streptozotocin-induced type 1 diabetic rats,” Journal of Nutritional Science and Vitaminology, vol. 46, no. 3, pp. 144–148, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. F. J. Quintana, E. Buzas, Z. Prohászka et al., “Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies,” Journal of Autoimmunity, vol. 22, no. 4, pp. 297–305, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. E. Brown, D. R. Stevens, and H. L. Haas, “The physiology of brain histamine,” Progress in Neurobiology, vol. 63, no. 6, pp. 637–672, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. A. K. Fülöp, A. Földes, E. Buzás et al., “Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene,” Endocrinology, vol. 144, no. 10, pp. 4306–4314, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Masaki, S. Chiba, T. Yasuda et al., “Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity,” Diabetes, vol. 53, no. 9, pp. 2250–2260, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Yoshimoto, Y. Miyamoto, K. Shimamura et al., “Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 37, pp. 13866–13871, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Jutel, T. Watanabe, S. Klunker et al., “Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors,” Nature, vol. 413, no. 6854, pp. 420–425, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. W. W. Busse and J. Sosman, “Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response,” Science, vol. 194, no. 4266, pp. 737–738, 1976. View at Publisher · View at Google Scholar · View at Scopus
  17. I. J. Elenkov, E. Webster, D. A. Papanicolaou, T. A. Fleisher, G. P. Chrousos, and R. L. Wilder, “Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors,” Journal of Immunology, vol. 161, no. 5, pp. 2586–2593, 1998. View at Google Scholar · View at Scopus
  18. W. Bäumer, S. Wendorff, R. Gutzmer et al., “Histamine H4 receptors modulate dendritic cell migration through skin: immunomodulatory role of histamine,” Allergy, vol. 63, no. 10, pp. 1387–1394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Gutzmer, C. Diestel, S. Mommert et al., “Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells,” The Journal of Immunology, vol. 174, no. 9, pp. 5224–5232, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Meng, Y. Han, D. Staloch, T. Francis, A. Stokes, and H. Francis, “The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis,” Hepatology, vol. 54, no. 5, pp. 1718–1728, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Adorini and S. Trembleau, “Immune deviation towards Th2 inhibits Th-1-mediated autoimmune diabetes,” Biochemical Society Transactions, vol. 25, no. 2, pp. 625–629, 1997. View at Google Scholar · View at Scopus
  22. R. J. Perry, X. M. Zhang, D. Zhang et al., “Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis,” Nature Medicine, vol. 20, no. 7, pp. 759–763, 2014. View at Publisher · View at Google Scholar
  23. H. Ohtsu, S. Tanaka, T. Terui et al., “Mice lacking histidine decarboxylase exhibit abnormal mast cells,” FEBS Letters, vol. 502, no. 1-2, pp. 53–56, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Schneider, F. Machavoine, J.-M. Pléau et al., “Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels,” Journal of Experimental Medicine, vol. 202, no. 3, pp. 387–393, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M.-A. Alyanakian, F. Grela, A. Aumeunier et al., “Transforming growth factor-β and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes,” Diabetes, vol. 55, no. 1, pp. 179–185, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Ramadan, L. Pham Van, F. MacHavoine et al., “Activation of basophils by the double-stranded RNA poly(A:U) exacerbates allergic inflammation,” Allergy, vol. 68, no. 6, pp. 732–738, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. X. D. Yang, W. Ai, S. Asfaha et al., “Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells,” Nature Medicine, vol. 17, no. 1, pp. 87–95, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Yin, G. Ma, C.-Y. Yen et al., “Myeloid-derived suppressor cells prevent type 1 diabetes in murine models,” The Journal of Immunology, vol. 185, no. 10, pp. 5828–5834, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. P. J. Dunford, N. O'Donnell, J. P. Riley, K. N. Williams, L. Karlsson, and R. L. Thurmond, “The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells,” Journal of Immunology, vol. 176, no. 11, pp. 7062–7070, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Coruzzi, M. Adami, and C. Pozzoli, “Role of histamine H4 receptors in the gastrointestinal tract,” Frontiers in Bioscience, vol. 4, no. 1, pp. 226–239, 2012. View at Google Scholar · View at Scopus
  31. D. S. Gill, C. S. Thompson, and P. Dandona, “Histamine synthesis and catabolism in various tissues in diabetic rats,” Metabolism, vol. 39, no. 8, pp. 815–818, 1990. View at Publisher · View at Google Scholar · View at Scopus
  32. T. M. Hollis and S. A. Strickberger, “Inhibition of aortic histamine synthesis by α-hydrazinohistidine inhibits increased aortic albumin accumulation in experimental diabetes in the rat,” Diabetologia, vol. 28, no. 5, pp. 282–285, 1985. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Matarese, V. Sanna, R. I. Lechler et al., “Leptin accelerates autoimmune diabetes in female NOD mice,” Diabetes, vol. 51, no. 5, pp. 1356–1361, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Trembleau, G. Penna, E. Bosi, A. Mortara, M. K. Gately, and L. Adorini, “Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice,” Journal of Experimental Medicine, vol. 181, no. 2, pp. 817–821, 1995. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Rabinovitch, W. L. Suarez-Pinzon, and O. Sorensen, “Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice,” Journal of Autoimmunity, vol. 9, no. 5, pp. 645–651, 1996. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Diana, Y. Simoni, L. Furio et al., “Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes,” Nature Medicine, vol. 19, no. 1, pp. 65–73, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. J. M. Cowden, F. Yu, H. Banie et al., “The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis,” Annals of the Rheumatic Diseases, vol. 73, no. 3, pp. 600–608, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Gutzmer, K. Langer, M. Lisewski et al., “Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells,” Journal of Allergy and Clinical Immunology, vol. 109, no. 3, pp. 524–531, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Gschwandtner, H. Bunk, B. Köther et al., “Histamine down-regulates IL-27 production in antigen-presenting cells,” Journal of Leukocyte Biology, vol. 92, no. 1, pp. 21–29, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Caron, Y. Delneste, E. Roelandts et al., “Histamine polarizes human dendritic cells into Th2 cell-promoting effector dendritic cells,” Journal of Immunology, vol. 167, no. 7, pp. 3682–3686, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. R.-R. Zhai, A.-P. Jiang, H.-B. Wang et al., “Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells,” Virology, vol. 442, no. 2, pp. 163–172, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. J. T. Morgan and D. G. Amaral, “Comparative analysis of the dendritic organization of principal neurons in the lateral and central nuclei of the rhesus macaque and rat amygdala,” Journal of Comparative Neurology, vol. 522, no. 3, pp. 689–716, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Adlesic, M. Verdrengh, M. Bokarewa, L. Dahlberg, S. J. Foster, and A. Tarkowski, “Histamine in rheumatoid arthritis,” Scandinavian Journal of Immunology, vol. 65, no. 6, pp. 530–537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. J. B. Perz and A. D. Ho, “Histamine dihydrochloride for the treatment of acute myeloid leukemia, malignant melanoma and renal cell carcinoma,” Future Oncology, vol. 4, no. 2, pp. 169–177, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. A. P. Bieneman, K. L. Chichester, Y.-H. Chen, and J. T. Schroeder, “Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion,” Journal of Allergy and Clinical Immunology, vol. 115, no. 2, pp. 295–301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Aumeunier, F. Grela, A. Ramadan et al., “Systemic toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice,” PLoS ONE, vol. 5, no. 7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Cooke, P. Tonks, F. M. Jones et al., “Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice,” Parasite Immunology, vol. 21, no. 4, pp. 169–176, 1999. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Hofstetter, M. B. Fasano, and E. A. Ottesen, “Modulation of the host response in human schistosomiasis. IV. Parasite antigen induces release of histamine that inhibits lymphocyte responsiveness in vitro,” Journal of Immunology, vol. 130, no. 3, pp. 1376–1380, 1983. View at Google Scholar · View at Scopus