Research Article
Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Diabetic Rats Impairs Glycolytic Flux and Promotes Glycogen Synthesis
Figure 1
Type 2 diabetes mellitus (T2DM) induces (a and b) glucose intolerance and (c and d) insulin resistance and significantly alters both (e) serum and testicular testosterone levels. (a) Blood glucose levels of the control group (▲) and T2DM group (●) measured during intraperitoneal glucose tolerance test. (b) Area under the curve for the intraperitoneal glucose tolerance test (AUCGTT) performed in control and T2DM group rats. (c) Blood glucose levels of the control group (▲) and T2DM group (●) measured during intraperitoneal insulin tolerance test. (d) Area under the curve for the intraperitoneal insulin tolerance test (AUCITT) performed in control and T2DM group rats. (e) Testosterone levels in intratesticular interstitial fluid and serum of control and T2DM group rats. (f) 17β-Estradiol levels in intratesticular interstitial fluid and serum of control and T2DM group rats. Results are presented as mean ± SEM of six independent experiments, corresponding to six animals/group. *Significantly different relative to control ().
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