Testicular Metabolic Reprogramming in Neonatal Streptozotocin-Induced Type 2 Diabetic Rats Impairs Glycolytic Flux and Promotes Glycogen Synthesis

Figure 3

Type 2 diabetes mellitus (T2DM) modulates the expression of lactate production-related enzymes and transporter. (a) Pooled data of independent experiments, indicating the fold variation of lactate dehydrogenase (LDH), alanine transaminase 2 (ALT2), and monocarboxylate transporter 4 (MCT4) mRNA levels found in testicles of T2DM rats when compared with the control rats (dashed line). (b) Pooled data of independent experiments, indicating the fold variation of LDH, ALT, and MCT4 protein levels found in testicles of T2DM rats when compared with the control rats (dashed line). (c) Illustrative Western Blot experiment. Results are expressed as mean ± SEM ( for each condition). *Significantly different relative to control ().

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