Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes

Figure 2

The effect of oleanolic acid, metformin, and their combination on the FSI level, FPG level, and HOMA-IR in db/db mice. (a) The FPG level was measured after 8 h of fasting in db/db mice treated with vehicle, oleanolic acid, metformin, or the combination for 4 weeks. (b) The FSI level was measured after 8 h of fasting in db/db mice treated with vehicle, oleanolic acid, metformin, or the combination for 4 weeks. (c) The HOMA-IR index was calculated for each group. Data are shown as the mean ± SEM. , , and indicate significant differences for comparisons with the vehicle group; indicates significant differences for comparisons with the monotherapy group ().

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