ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes

Figure 1

ALDH2 inhibition by pretreating with disulfiram (DSF) and reactive oxygen species (ROS) levels. (a) Representative photomicrographs of DCF stained cells from respective treatments. (b) Increase in ROS in cultured H9C2 cardiomyocytes subjected to high glucose stress (G2) compared to equimolar mannitol (G1). Disulfiram (DSF) pretreatment increased ROS levels in both mannitol (G3) and high glucose (G4) groups. The data expressed are mean ± SEM. = 4–6. versus G1, versus G2, and versus G3.

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