Table 4: Prevalence of hypothyroidism, TSH, and FT4 in subgroups of hypothyroid patients with diabetes.

Subgroups of antidiabetes drugs values
MTFSU/DPP4/TZDINSMTF+

Hypothyroidism (%/)4.5% (10/224)6.5% (14/215)7.5% (4/53)6.6% (17/259)MTF × other groups < 0.05
MTF+ × other groups NS

TSH (mU/L)
 Median11.815.017.513.5MTF × other groups < 0.05
INS × other groups < 0.05
MTF+ × other groups NS
 25–75%11.6–14.211.2–17.113.2–19.311.7–15.6
 95% CI11.5–13.714.5–15.517.0–18.012.9–15.9

FT4 (pmol/L)
 Mean11.711.19.810.9NS
 SD±0.5±0.5±1.3±1.3
 95% CI10.3–15.410.3–15.49.0–11.69.0–11.6

TSH: thyroid stimulating hormone; FT4: free thyroxine; 25–75%: 25–75 percentiles CI: confidence interval; NS: not significant. MTF: metformin; SU/DPP4/TZD: sulfonylureas, dipeptidyl peptidase 4 (DPP4) inhibitors, and thiazolidinedione analyzed together. For converting FT4 in nd/dL, multiply pmol/L by 0.078.