Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Figure 4

(a) Immunofluorescent staining for insulin (red color) and BrdU (green color) in human islet grafts from PSN632408- and vehicle-treated mice with normoglycemia at 4 weeks after transplantation. White arrows show insulin/BrdU copositive cells in human islet grafts. (b) Percentage of insulin/BrdU copositive cells among total insulin positive cells in human islet grafts. The average percent of insulin/BrdU copositive cells among total insulin positive cells was significantly higher in PSN632408-treated mice () compared with vehicle-treated mice () ().

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