Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Figure 6

(a) Immunofluorescent staining for insulin (red color) and CK19 (green color) in human islet grafts in PSN632408- and vehicle-treated mice with normoglycaemia at 4 weeks after transplantation. White arrows show insulin/CK19 copositive cells in human islets grafts. (b) Percentage of insulin/CK19 copositive cells among total CK19 positive duct cells in human islet grafts. The average percent of insulin/CK19 copositive cells among total CK19 positive duct cells was significantly higher in mice treated with PSN632408 () compared with mice treated with vehicle () ().

(a)

(b)