Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Figure 8

(a) Immunofluorescent staining for glucagon (green color), BrdU (red color), and DAPI (blue color) in human islet grafts from PSN632408- and vehicle-treated mice with normoglycaemia at 4 weeks after transplantation. White arrows show glucagon/BrdU copositive cells in human islet grafts. (b) Percentage of glucagon/BrdU copositive cells among total glucagon positive cells in human islet grafts. The average percent of glucagon/BrdU copositive cells among total glucagon positive cells was significantly higher in PSN632408-treated mice () compared with vehicle-treated mice () ().

(a)

(b)