Vitamin B6 Prevents Endothelial Dysfunction, Insulin Resistance, and Hepatic Lipid Accumulation in Apoe^−/− Mice Fed with High-Fat Diet

Figure 2

VitB6 improves insulin resistance in mice fed with high-fat diet. Male mice at the age of 6 weeks received high-fat diet and VitB6 (50 mg/kg/day) administration in drinking water. At the 8th weekend after VitB6 treatment, (a) GTT and (b) ITT were evaluated as described in Section 2. All data were expressed as mean ± SEM. is 10–15 in each group. versus control. (c) Homogenates of liver tissues were subjected to perform western blotting analysis to assay the levels of pAKt, GLUT4, GSK3, and FOXO. The picture is a representative blot from 10–15 mice.

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