Research Article

Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers

Figure 4

The -positions of the Cα atom (black) and the side chain centroid (red) of each amino acid residue of hIAPP at POPC bilayer surface. For each membrane binding orientation (Fa, Fb, Fc, and Fd), the -position is averaged using the last 20 ns data of each MD run (see Table 1). The green and blue dashed lines correspond, respectively, to the average position of phosphorus atoms and that of carbon atoms of the ester group of lipids, between which is the headgroup region of the upper leaflet. The residues that have a smaller -position relative to their adjacent residues in the helical 8–20 region are labeled in the figure.