Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy

Figure 6

Gene expressions of kidneys. The mRNA expression levels were measured by qRT-PCR and normalized to TATA-binding protein (Tbp). Following primer sets were used for the detection (Table 1): glyoxalase 1 (Glo1), toll-like receptor 4 (Tlr4), interleukin (Il)1b, Il10, vascular cell adhesion molecule- (Vcam-) 1, monocyte chemoattractant protein- (MCP-) 1, Mcp-2, C-C chemokine receptor type 2 (Ccr2), and collagen 1a1 (Col1a1). Nondiabetic control (Control) (), diabetic mice without treatment (DM) (), diabetic mice with insulin treatment (DM + Ins) (), diabetic mice with salicylate treatment (DM + Sal) (), and diabetic mice with pyridoxamine treatment (DM + Pyrid) (). Values are mean ± SEM.