Inhibition of NA⁺/H⁺ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

Figure 2

Ex vivo inhibition of NHE1 by cariporide reverses AGEs-increased LDH leakage in rat renal cortex. Sliced renal cortex was incubated with BSA, H-car (1 μM cariporide), L-car (0.1 μM cariporide), and Ab-RAGE (antibody of AGEs receptor). After treatment, (a) LDH leakage and NHE1 protein expression, (b) GSH content, (c) MAD level, and (d) NHE1 activity were measured, respectively. All data were expressed as mean ± SD. is 5 in each group. versus BSA. versus AGEs alone.

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