Inhibition of NA⁺/H⁺ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

Figure 3

Inhibition of NHE1 improves AGEs-induced abnormality of glomerular structure in rats. The rats received a tail vein injection of AGEs (100 mg/kg) followed by treatment with or without N-acetylcysteine (200 mg/kg/day) or cariporide (1 mg/kg/day) for 12 weeks. At the end of experiments, rats were sacrificed under anesthesia. (a) Morphology of glomerular in kidney by HE staining. (b) Mesangial matrix injury score, (c) cell numbers in glomerular, and (d) glomerular volume were determined. Data are expressed as mean ± S.E.M. is 10–15 in each group. versus BSA. versus AGEs alone.

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