Inhibition of NA⁺/H⁺ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

Figure 4

In vivo administration of cariporide prevents renal dysfunction in AGEs-injected rats. The rats received a tail vein injection of AGEs (100 mg/kg) followed by treatment with or without N-acetylcysteine (200 mg/kg/day) or cariporide (1 mg/kg/day) for 12 weeks. At the end of experiments, (a) serum creatinine level, (b) blood urea nitrogen, (c) urinary protein excretion, and (d) clearance of creatinine were measured, respectively. All data were expressed as mean ± SD. is 5 in each group. versus BSA. versus AGEs alone.

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(b)

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