Inhibition of NA⁺/H⁺ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

Figure 5

Cariporide recues AGEs-induced oxidative stress in kidney of rats. The rats received a tail vein injection of AGEs (100 mg/kg) followed by treatment with or without N-acetylcysteine (200 mg/kg/day) or cariporide (1 mg/kg/day) for 12 weeks. At the end of experiments, rats were sacrificed under anesthesia. (a) GSH content and (b) MAD level were determined. All data were expressed as mean ± SD. is 10–15 in each group. versus BSA. versus AGEs alone.

(a)

(b)