Inhibition of NA⁺/H⁺ Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats

Table 1

General parameters in rats.

Groups	BG (mM)	BW (g)	KI (g/kg)
Vehicle	5.71 ± 0.59	385.81 ± 11.67	3.18 ± 0.272
BSA	5.94 ± 0.67	383.35 ± 9.59	3.41 ± 0.194
AGEs	6.07 ± 0.71	356.40 ± 5.94	5.07 ± 0.537
AGEs + NAC	5.29 ± 0.32	368.35 ± 4.38	3.75 ± 0.237^#
AGEs + car	5.80 ± 0.54	373.80 ± 3.10	3.62 ± 0.142^#

The rats received a tail vein injection of AGEs (100 mg/kg) followed by treatment with N-acetylcysteine (200 mg/kg/day) or cariporide (1 mg/kg/day). 12 weeks later, all rats were sacrificed under anesthesia and blood glucose (BG), body weight (BW), and kidney index (KI) were determined. All data were expressed as mean ± SD. is 10–15 in each group. versus BSA. ^# versus AGEs alone.