Mechanism Investigation of the Improvement of Chang Run Tong on the Colonic Remodeling in Streptozotocin-Induced Diabetic Rats

Table 5

Multiple linear regression analysis for the relation between expressions of AGE, RAGE, TGF-β1, and TGF-β1 receptor with other parameters.

Parameter	Multiple linear regression equation	values	values	values	Independent
Glucose	Glu = 8.960 + (57.741 AGE-M) + (82.058 RAGE-M) + (10.561 TGF-M) − (26.793 TGFR-M)	0.696	3.201	0.032	AGE-M; RAGE-M; TGF-M; TGFR-M	0.103; 0.042; 0.671; 0.371
	Glu = 12.108 + (26.395 AGE-Mu) + (23.614 RAGE-Mu) − (4.778 TGF-Mu) − (12.056 TGFR-Mu)	0.762	4.693	0.007	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.037; 0.086; 0.765; 0.552
	Glu = 13.082 + (48.264 AGE-Sub) + (42.375 RAGE-Sub) + (12.137 TGF-Sub) − (15.258 TGFR-Sub)	0.748	4.314	0.010	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.197; 0.030; 0.523; 0.522
Wall area	W-a = 10.385 + (12.595 AGE-M) + (29.805 RAGE-M) + (14.784 TGF-M) − (8.557 TGFR-M)	0.797	5.909	0.002	AGE-M; RAGE-M; TGF-M; TGFR-M	0.160; 0.006; 0.030; 0.268
	W-a = 10.615 + (10.314 AGE-Mu) + (1.876 RAGE-Mu) + (1.158 TGF-Mu) + (2.991 TGFR-Mu)	0.706	3.377	0.027	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.016; 0.668; 0.828; 0.656
	W-a = 10.180 + (21.961 AGE-Sub) + (6.459 RAGE-Sub) + (0.864 TGF-Sub) + (5.357 TGFR-Sub)	0.746	4.258	0.011	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.062; 0.253; 0.881; 0.463
Outer residual strain	res-out = 0.0647 + (0.557 AGE-M) + (0.706 RAGE-M) + (0.663 TGF-M) − (0.463 TGFR-M)	0.808	6.411	0.002	AGE-M; RAGE-M; TGF-M; TGFR-M	0.039; 0.021; 0.002; 0.048
	res-out = 0.104 + (0.377 AGE-Mu) − (0.0391 RAGE-Mu) − (0.0109 TGF-Mu) − (0.101 TGFR-Mu)	0.697	3.220	0.032	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.005; 0.766; 0.945; 0.619
	res-out = 0.0843 + (1.013 AGE-Sub) − (0.0550 RAGE-Sub) + (0.167 TGF-Sub) − (0.0130 TGFR-Sub)	0.738	4.076	0.013	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.007; 0.742; 0.345; 0.953
Opening angle	OA = 100.128 + (219.169 AGE-M) + (463.871 RAGE-M) + (218.084 TGF-M) − (101.125 TGFR-M)	0.643	2.394	0.081	AGE-M; RAGE-M; TGF-M; TGFR-M	0.337; 0.078; 0.196; 0.607
	OA = 81.341 + (200.133 AGE-Mu) − (27.827 RAGE-Mu) − (105.944 TGF-Mu) + (299.716 TGFR-Mu)	0.814	6.690	0.001	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.007; 0.704; 0.243; 0.015
	OA = 66.919 + (310.291 AGE-Sub) + (112.010 RAGE-Sub) − (109.444 TGF-Sub) + (276.150 TGFR-Sub)	0.716	3.576	0.022	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.204; 0.351; 0.380; 0.088
C-constant α	C-α = 1.106 + (2.058 AGE-M) + (3.470 RAGE-M) + (4.103 TGF-M) − (0.635 TGFR-M)	0.499	1.127	0.384	AGE-M; RAGE-M; TGF-M; TGFR-M	0.587; 0.415; 0.149; 0.847
	C-α = 0.851 + (2.003 AGE-Mu) + (1.678 RAGE-Mu) + (2.208 TGF-Mu) − (0.0908 TGFR-Mu)	0.608	1.991	0.132	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.145; 0.266; 0.230; 0.968
	C-α = 0.845 + (6.500 AGE-Sub) + (0.222 RAGE-Sub) + (1.132 TGF-Sub) + (1.359 TGFR-Sub)	0.607	1.985	0.133	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.119; 0.911; 0.588; 0.604
L-constant α	L-α = 12.292 + (151.852 AGE-M) − (12.161 RAGE-M) − (19.859 TGF-M) − (3.768 TGFR-M)	0.560	1.555	0.226	AGE-M; RAGE-M; TGF-M; TGFR-M	0.028; 0.866; 0.673; 0.946
	L-α = 13.874 + (32.678 AGE-Mu) + (34.214 RAGE-Mu) + (55.419 TGF-Mu) − (13.298 TGFR-Mu)	0.628	2.119	0.113	AGE-Mu; RAGE-Mu; TGF-Mu; TGFR-Mu	0.176; 0.200; 0.094; 0.740
	L-α = 21.304 + (4.899 AGE-Sub) + (57.401 RAGE-Sub) + (32.987 TGF-Sub) − (21.109 TGFR-Sub)	0.526	1.301	0.309	AGE-Sub; RAGE-Sub; TGF-Sub; TGFR-Sub	0.949; 0.145; 0.411; 0.672

Notes: M, mucosa; Mu, muscle; Sub, submucosa; Glu, glucose; W-a, wall area; Res-out, outer residual strain; OA, opening angle, C-α, circumferential constant α; L-α, longitudinal constant α.