The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells
Autophagy plays a prosurvival role in AS- and PS-mediated cell outcome. (a) NIT-1 cells in AS exhibited substantially decreased cell viability. When pretreated with DPQ or RAPA, the cells increased in number; the autophagy inhibitor BAF-A1 mildly reduced cell viability. DPQ or RAPA exhibited increased cell viability in 20 μM PS-treated cells, and BAF-A1 exhibited a mild decrease in cell viability. (b) LDH activity release in the NIT-1 cells after treatment with AS with or without DPQ, BAF-A1, and RAPA; DPQ and RAPA pretreatment significantly reduced LDH activity release; BAF-A1 significantly increased LDH activity release. Similarly, BAF-A1 significantly increased LDH activity release in NIT-1 cells treated with PS for 48 h, and RAPA pretreatment can attenuate BAF-A1-associated increase in LDH activity release. DPQ did not change the percentage of LDH activity release. The value for the CON group was set at 1. , compared to the only AS- or PS-treated group; mean ± SD from three replicates.
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