Journal of Diabetes Research / 2016 / Article / Fig 8

Research Article

The Different Effects of Atorvastatin and Pravastatin on Cell Death and PARP Activity in Pancreatic NIT-1 Cells

Figure 8

Illustration of the mechanisms of AS- and PS-induced autophagy and cell death. AS- and PS-induced autophagy and cell death are mediated by PARP1 activation, ATP depletion, AMPK activation, and mTOR and RIP1-RIP3-MLKL suppression.

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