Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide

Figure 8

Interaction between hIAPP and EGCG. (a) Aromatic regions of ¹H NMR spectra of 100 μM hIAPP with (top) and without (bottom) 1 mM EGCG. One (), two (), and three () asterisks represent of His18, , and of Phe15/Phe23 residues, respectively. (b) ¹H NMR spectra of 1 mM EGCG in ratio of [hIAPP] : [EGCG] of 0 (bottom), 0.02 (medial), and 0.1 (top) μM hIAPP within chemical shift from 6.47 to 6.95 ppm in D₂O under 25°C.

(a)

(b)