Research Article

miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

Box 1

Significant KEGG pathways collectively targeted by miRNAs regulated by glucose in human islets, from DIANA miRPath v3.0 (http://snf-515788.vm.okeanos.grnet.gr/dianauniverse/index.php?r=mirpath).
KEGG pathways targeted by downregulated miRNAs
Adherence junction (hsa04520)
Biotin metabolism (hsa00780)
Glycosphingolipid biosynthesis, lacto- and neolactoseries (hsa00601)
Pancreatic secretion (hsa04972)
Protein processing in endoplasmic reticulum (hsa04141)
Ubiquitin mediated proteolysis (hsa04120)
Rap1 signaling pathway (hsa04015)
Thyroid hormone signaling pathway (hsa04919)
ā€‰
KEGG pathways targeted by upregulated miRNAs
Axon guidance (hsa04360)
Mucin type O-glycan biosynthesis (hsa00512)
Valine, leucine, and isoleucine biosynthesis (hsa00290)
Circadian rhythm (hsa04710)
ECM-receptor interaction (hsa04512)
Gap junction (hsa04540)
Focal adhesion (hsa04510)
Estrogen signaling pathway (hsa04915)
Hippo signaling pathway (hsa04390)
FoxO signaling pathway (hsa04068)
mTOR signaling pathway (hsa04150)
Wnt signaling pathway (hsa04310)
Signaling pathways regulating pluripotency of stem cells (hsa04550)
TGF-beta signaling pathway (hsa04350)
PI3K-Akt signaling pathway (hsa04151)
Prion diseases (hsa05020)
Viral carcinogenesis (hsa05203)
Hepatitis B (hsa05161)
Chronic myeloid leukemia (hsa05220)
Glioma (hsa05214)
Melanoma (hsa05218)
Non-small cell lung cancer (hsa05223)
Pancreatic cancer (hsa05212)
Pathways in cancer (hsa05200)
Prostate cancer (hsa05215)
Proteoglycans in cancer (hsa05205)
Renal cell carcinoma (hsa05211)
Thyroid cancer (hsa05216)
Transcriptional misregulation in cancer (hsa05202)