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Journal of Diabetes Research
Volume 2016, Article ID 1869082, 7 pages
http://dx.doi.org/10.1155/2016/1869082
Research Article

miRNA-375 a Sensor of Glucotoxicity Is Altered in the Serum of Children with Newly Diagnosed Type 1 Diabetes

1CarMeN Laboratory (INSERM 1060, INRA 1362, INSA), Lyon-Sud Faculty of Medicine, University of Lyon, Chemin du Grand Revoyet, 69600 Oullins, France
2Hospices Civils de Lyon, Lyon-Sud Hospital, Department of Diabetology and Endocrinology, 69495 Pierre-Bénite, France
3Hospices Civils de Lyon, Department of Pediatric Endocrinology, Femme-Mère-Enfant Hospital, 69500 Bron, France
4Hospices Civils de Lyon, INSERM U851, Lyon-Sud Hospital, Department of Immunology, 69495 Pierre-Bénite, France

Received 18 January 2016; Revised 11 March 2016; Accepted 19 April 2016

Academic Editor: Paolo Fiorina

Copyright © 2016 Lucien Marchand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Atkinson, G. S. Eisenbarth, and A. W. Michels, “Type 1 diabetes,” The Lancet, vol. 383, no. 9911, pp. 69–82, 2014. View at Publisher · View at Google Scholar
  2. B. Buckingham, R. W. Beck, K. J. Ruedy et al., “Effectiveness of early intensive therapy onb-cell preservation in type 1 diabetes,” Diabetes Care, vol. 36, no. 12, pp. 4030–4035, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. P. In’t Veld, “Insulitis in human type 1 diabetes: a comparison between patients and animal models,” Seminars in Immunopathology, vol. 36, no. 5, pp. 569–579, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Willcox, S. J. Richardson, A. J. Bone, A. K. Foulis, and N. G. Morgan, “Analysis of islet inflammation in human type 1 diabetes,” Clinical & Experimental Immunology, vol. 155, no. 2, pp. 173–181, 2009. View at Publisher · View at Google Scholar
  5. M. Campbell-Thompson, C. Wasserfall, J. Kaddis et al., “Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes,” Diabetes/Metabolism Research and Reviews, vol. 28, no. 7, pp. 608–617, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Weber, D. H. Baxter, S. Zhang et al., “The microRNA spectrum in 12 body fluids,” Clinical Chemistry, vol. 56, no. 11, pp. 1733–1741, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Wang, S. Zhang, B. Marzolf et al., “Circulating microRNAs, potential biomarkers for drug-induced liver injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 11, pp. 4402–4407, 2009. View at Publisher · View at Google Scholar
  9. L. N. L. Van Aelst and S. Heymans, “MicroRNAs as biomarkers for ischemic heart disease,” Journal of Cardiovascular Translational Research, vol. 6, no. 4, pp. 458–470, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Ferracin, A. Veronese, and M. Negrini, “Micromarkers: miRNAs in cancer diagnosis and prognosis,” Expert Review of Molecular Diagnostics, vol. 10, no. 3, pp. 297–308, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Geekiyanage, G. A. Jicha, P. T. Nelson, and C. Chan, “Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease,” Experimental Neurology, vol. 235, no. 2, pp. 491–496, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. R. M. O'Connell, D. S. Rao, and D. Baltimore, “microRNA regulation of inflammatory responses,” Annual Review of Immunology, vol. 30, pp. 295–312, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Villard, L. Marchand, C. Thivolet, and S. Rome, “Diagnostic value of cell-free circulating micrornas for obesity and type 2 diabetes: a meta-analysis,” Journal of Molecular Biomarkers & Diagnosis, vol. 6, article 251, 2015. View at Publisher · View at Google Scholar
  14. L. B. Nielsen, C. Wang, K. Sørensen et al., “Circulating levels of microRNA from children with newly diagnosed type 1 diabetes and healthy controls: evidence that miR-25 associates to residual beta-cell function and glycaemic control during disease progression,” Experimental Diabetes Research, vol. 2012, Article ID 896362, 7 pages, 2012. View at Publisher · View at Google Scholar
  15. J. Osipova, D.-C. Fischer, S. Dangwal et al., “Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study,” Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. E1661–E1665, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. M. N. Poy, L. Eliasson, J. Krutzfeldt et al., “A pancreatic islet-specific microRNA regulates insulin secretion,” Nature, vol. 432, no. 7014, pp. 226–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. M. N. Poy, J. Hausser, M. Trajkovski et al., “miR-375 maintains normal pancreatic alpha- and beta-cell mass,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 14, pp. 5813–5818, 2009. View at Google Scholar
  18. V. A. Salunkhe, J. L. S. Esguerra, J. K. Ofori et al., “Modulation of microRNA-375 expression alters voltage-gated Na+ channel properties and exocytosis in insulin-secreting cells,” Acta Physiologica, vol. 213, no. 4, pp. 882–892, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Hoseki, R. Ushioda, and K. Nagata, “Mechanism and components of endoplasmic reticulum-associated degradation,” Journal of Biochemistry, vol. 147, no. 1, pp. 19–25, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Deo, J. Carlsson, and A. Lindlöf, “How to choose a normalization strategy for miRNA quantitative real-time (qPCR) arrays,” Journal of Bioinformatics and Computational Biology, vol. 9, no. 6, pp. 795–812, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. L. S. Esguerra, C. Bolmeson, C. M. Cilio, and L. Eliasson, “Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat,” PLoS ONE, vol. 6, no. 4, Article ID e18613, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. C. Coggeshall, J. P. Heggers, M. C. Robson, and H. Baker, “Biotin status and plasma glucose in diabetics,” Annals of the New York Academy of Sciences, vol. 447, no. 1, pp. 389–392, 1985. View at Publisher · View at Google Scholar
  23. E. Boslem, P. J. Meikle, and T. J. Biden, “Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction,” Islets, vol. 4, no. 3, pp. 177–187, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Erener, M. Mojibian, J. K. Fox, H. C. Denroche, and T. J. Kieffer, “Circulating miR-375 as a biomarker of β-cell death and diabetes in mice,” Endocrinology, vol. 154, no. 2, pp. 603–608, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. M. van de Bunt, K. J. Gaulton, L. Parts et al., “The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis,” PLoS ONE, vol. 8, no. 1, article e55272, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Flowers, G. Y. Won, and Y. Fukuoka, “Micrornas associated with exercise and diet: a systematic review,” Physiological Genomics, vol. 47, no. 1, pp. 1–11, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Kong, J. Zhu, W. Han et al., “Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study,” Acta Diabetologica, vol. 48, no. 1, pp. 61–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Carreras-Badosa, A. Bonmatí, F. J. Ortega et al., “Altered circulating miRNA expression profile in pregestational and gestational obesity,” The Journal of Clinical Endocrinology & Metabolism, vol. 100, no. 11, pp. E1446–E1456, 2015. View at Publisher · View at Google Scholar
  29. M. Latreille, K. Herrmanns, N. Renwick et al., “miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development,” Journal of Molecular Medicine, vol. 93, no. 10, pp. 1159–1169, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Higuchi, A. Nakatsuka, J. Eguchi et al., “Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes,” Metabolism: Clinical and Experimental, vol. 64, no. 4, pp. 489–497, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. D. S. Karolina, A. Armugam, S. Tavintharan et al., “MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus,” PLoS ONE, vol. 6, no. 8, Article ID e22839, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Guay, V. Menoud, S. Rome, and R. Regazzi, “Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells,” Cell Communication and Signaling, vol. 13, no. 1, article 17, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Latreille, K. Herrmanns, N. Renwick et al., “miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development,” Journal of Molecular Medicine, vol. 93, no. 10, pp. 1159–1169, 2015. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. Liang, D. Ridzon, L. Wong, and C. Chen, “Characterization of microRNA expression profiles in normal human tissues,” BMC Genomics, vol. 8, article 166, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Fiorina, A. M. J. Shapiro, C. Ricordi, and A. Secchi, “The clinical impact of islet transplantation,” American Journal of Transplantation, vol. 8, no. 10, pp. 1990–1997, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. M. J. I. Ansari, P. Fiorina, S. Dada et al., “Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice,” Clinical Immunology, vol. 126, no. 2, pp. 140–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Fiorina, A. Vergani, S. Dada et al., “Targeting CD22 reprograms B-cells and reverses autoimmune diabetes,” Diabetes, vol. 57, no. 11, pp. 3013–3024, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Vergani, F. D'Addio, M. Jurewicz et al., “A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice,” Diabetes, vol. 59, no. 9, pp. 2253–2264, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Reynier, A. Pachot, M. Paye et al., “Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis,” Genes and Immunity, vol. 11, no. 3, pp. 269–278, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. A. Atkinson, M. von Herrath, A. C. Powers, and M. Clare-Salzler, “Current concepts on the pathogenesis of type 1 diabetes—considerations for attempts to prevent and reverse the disease,” Diabetes Care, vol. 38, no. 6, pp. 979–988, 2015. View at Publisher · View at Google Scholar
  41. L.-M. Li, Z.-B. Hu, Z.-X. Zhou et al., “Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma,” Cancer Research, vol. 70, no. 23, pp. 9798–9807, 2010. View at Publisher · View at Google Scholar · View at Scopus