Levels of Serum 25(OH)VD₃, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio

Table 5

Relationship between serum levels of HIF-1α, VEGF, vWF, IGF-1, and 25(OH)VD₃ and various factors.

Variable	HIF-1α		VEGF		IGF-1		25(OH)VD3		vWf
	r	P	r	P	r	P	r	P	r	P
Duration	0.113	=0.011	0.123	=0.006	0.136	=0.002	−0.097	=0.031	0.027	<0.001
FBG	0.098	=0.028	0.024	=0.590	0.103	=0.021	−0.047	=0.298	0.092	=0.039
HbA1c	0.010	=0.824	0.091	=0.040	0.063	=0.156	−0.016	=0.716	0.081	=0.069
HDL	0.090	=0.043	−0.019	=0.672	0.012	=0.794	−0.008	=0.857	0.040	=0.377
LDL	0.111	=0.013	0.151	=0.001	0.131	=0.003	−0.016	=0.726	0.142	=0.001
TC	0.143	=0.001	0.248	<0.001	0.223	<0.001	−0.038	=0.400	0.190	<0.001
TG	0.051	=0.254	0.084	=0.060	0.105	=0.019	−0.084	=0.060	0.293	<0.001
UA	0.038	=0.402	0.201	<0.001	0.180	<0.001	−0.069	=0.123	0.280	<0.001
Scr	0.174	<0.001	0.253	<0.001	0.207	<0.001	−0.103	=0.020	0.266	<0.001
BUN	0.328	<0.001	0.367	<0.001	0.364	<0.001	−0.153	=0.001	0.426	<0.001
eGFR	−0.194	<0.001	−0.307	<0.001	−0.246	<0.001	0.101	0.024	−0.322	<0.001
Fg	0.278	<0.001	0.239	<0.001	0.272	<0.001	−0.067	=0.131	0.248	<0.001
Ln(ACR)	0.525	<0.001	0.715	<0.001	0.630	<0.001	−0.285	<0.001	0.748	<0.001
FINS	0.137	=0.002	−0.087	=0.051	−0.105	=0.019	−0.018	=0.689	0.036	=0.415
HOMA-IR	−0.038	=0.394	−0.058	=0.193	−0.152	=0.001	−0.004	=0.929	0.072	=0.109

FBG: fasting blood glucose; HbA1c: glycated hemoglobin; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TC: cholesterol; TG: triglyceride; UA: uric acid; Scr: serum creatinine; BUN: blood urea nitrogen; eGFR: estimated glomerular filtration rate; Fg: fibrinogen; Ln(ACR): Ln Koc of urinary albumin to creatinine ratio; FINS: fasting insulin; HOMA-IR: HOMA insulin resistance index; HIF-1α: hypoxia-inducible factor-1α; VEGF: vascular endothelial growth factor; IGF-1: insulin-like growth factor-1; 25(OH)VD₃: 25-hydroxy vitamin D₃; vWf: von Willebrand factor.