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Journal of Diabetes Research
Volume 2016 (2016), Article ID 2029854, 14 pages
http://dx.doi.org/10.1155/2016/2029854
Research Article

Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

1Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325035, China
2Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang 325035, China
3Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang 325035, China
4Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Received 6 February 2015; Revised 12 June 2015; Accepted 1 July 2015

Academic Editor: Laurent Crenier

Copyright © 2016 Jinshuang Bo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite this Article

Jinshuang Bo, Shiya Xie, Yi Guo, et al., “Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs,” Journal of Diabetes Research, vol. 2016, Article ID 2029854, 14 pages, 2016. doi:10.1155/2016/2029854