Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Figure 4

Effects of MG on the production of ATP by MIN6 cells. Reduction of ATP production by MG depended on MG concentration. The effects of MG were reversed by coincubation with NAC. compared to control group (0 mM MG + 0 mM NAC). compared to the higher MG group (0.1 mM MG + 0 mM NAC).