Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Figure 7

Time-dependent effects of MG on expression of p-JNK, JNK, p-P38, and P38 proteins in MIN6 cells. The expression of p-JNK and JNK (a) and p-P38 and P38 (d) was increased after treatment with MG for 1 h. Cells were incubated with 0.1 mM MG for 1, 2, and 3 h. Results shown in (b), (c), (e), and (f) are fold change compared to baseline (0 mM MG). , , and compared to control group (0 mM MG).

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