Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

Figure 8

Effects of H₂O₂ on ROS production (a), apoptotic rate (b), and expression of MAPK in MIN6 cells. Results shown in (a), (b), (d), (e), (g), and (h) are fold change compared to baseline (0 mM H₂O₂ + 0 mM NAC). , compared to control group (0 mM H₂O₂ + 0 mM NAC). , compared to H₂O₂ group (0.2 mM H₂O₂ + 0 mM NAC).

(a)

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(h)