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Journal of Diabetes Research
Volume 2016 (2016), Article ID 2029854, 14 pages
http://dx.doi.org/10.1155/2016/2029854
Research Article

Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

1Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang 325035, China
2Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou, Zhejiang 325035, China
3Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou, Zhejiang 325035, China
4Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Received 6 February 2015; Revised 12 June 2015; Accepted 1 July 2015

Academic Editor: Laurent Crenier

Copyright © 2016 Jinshuang Bo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Shi and F. B. Hu, “The global implications of diabetes and cancer,” The Lancet, vol. 383, no. 9933, pp. 1947–1948, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Aguiree, A. Brown, N. H. Cho et al., IDF Diabetes Atlas, International Diabetes Federation, 2013.
  3. M. Stumvoll, B. J. Goldstein, and T. W. van Haeften, “Type 2 diabetes: principles of pathogenesis and therapy,” The Lancet, vol. 365, no. 9467, pp. 1333–1346, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. J. S. Lee, Y. R. Kim, J. M. Park et al., “Mulberry fruit extract protects pancreatic β-cells against hydrogen peroxide-induced apoptosis via antioxidative activity,” Molecules, vol. 19, no. 7, pp. 8904–8915, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Prentki and C. J. Nolan, “Islet β cell failure in type 2 diabetes,” Journal of Clinical Investigation, vol. 116, no. 7, pp. 1802–1812, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Sakuraba, H. Mizukami, N. Yagihashi, R. Wada, C. Hanyu, and S. Yagihashi, “Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients,” Diabetologia, vol. 45, no. 1, pp. 85–96, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. P. J. Thornalley, “The glyoxalase system in health and disease,” Molecular Aspects of Medicine, vol. 14, no. 4, pp. 287–371, 1993. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Rodrigues, P. Matafome, D. Santos-Silva, C. Sena, and R. Seiça, “Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions,” Journal of Diabetes Research, vol. 2013, Article ID 690650, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Wang, Q. H. Meng, J. R. Gordon, H. Khandwala, and L. Wu, “Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus,” Clinical Biochemistry, vol. 40, no. 16-17, pp. 1232–1239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M.-P. Lu, R. Wang, X. Song, X. Wang, L. Wu, and Q. H. Meng, “Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 18, no. 9, pp. 618–623, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Lu, E. Randell, Y. Han, K. Adeli, J. Krahn, and Q. H. Meng, “Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy,” Clinical Biochemistry, vol. 44, no. 4, pp. 307–311, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Dhar, I. Dhar, K. M. Desai, and L. Wu, “Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose,” British Journal of Pharmacology, vol. 161, no. 8, pp. 1843–1856, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Chang, R. Wang, and L. Wu, “Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells,” Free Radical Biology & Medicine, vol. 38, no. 2, pp. 286–293, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. C. B. Chan, M. C. Saleh, V. Koshkin, and M. B. Wheeler, “Uncoupling protein 2 and islet function,” Diabetes, vol. 53, supplement 1, pp. S136–S142, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. R. E. Gimeno, M. Dembski, X. Weng et al., “Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis,” Diabetes, vol. 46, no. 5, pp. 900–906, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Nishikawa, D. Edelstein, X. L. Du et al., “Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage,” Nature, vol. 404, no. 6779, pp. 787–790, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Arsenijevic, H. Onuma, C. Pecqueur et al., “Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production,” Nature Genetics, vol. 26, no. 4, pp. 435–439, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Samec, J. Seydoux, and A. G. Dulloo, “Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?” The FASEB Journal, vol. 12, no. 9, pp. 715–724, 1998. View at Google Scholar · View at Scopus
  19. C. B. Chan, P. E. MacDonald, M. C. Saleh, D. C. Johns, E. Marbàn, and M. B. Wheeler, “Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets,” Diabetes, vol. 48, no. 7, pp. 1482–1486, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. R. P. Robertson, J. Harmon, P. O. T. Tran, and V. Poitout, “β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes,” Diabetes, vol. 53, supplement 1, pp. S119–S124, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Hou, S. Torii, N. Saito, M. Hosaka, and T. Takeuchi, “Reactive oxygen species-mediated pancreatic β-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-jun N-terminal kinase, and mitogen-activated protein kinase phosphatases,” Endocrinology, vol. 149, no. 4, pp. 1654–1665, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. C. R. Weston and R. J. Davis, “The JNK signal transduction pathway,” Current Opinion in Cell Biology, vol. 19, no. 2, pp. 142–149, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Zhou, X. Cai, X. Han, and L. Ji, “P38 plays an important role in glucolipotoxicity-induced apoptosis in INS-1 cells,” Journal of Diabetes Research, vol. 2014, Article ID 834528, 7 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Wang, Q. H. Meng, T. Chang, and L. Wu, “Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells,” Life Sciences, vol. 79, no. 26, pp. 2448–2454, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Wang, J. Liu, and L. Wu, “Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells,” Biochemical Pharmacology, vol. 77, no. 11, pp. 1709–1716, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Samuni, S. Goldstein, O. M. Dean, and M. Berk, “The chemistry and biological activities of N-acetylcysteine,” Biochimica et Biophysica Acta—General Subjects, vol. 1830, no. 8, pp. 4117–4129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. K. S. Suh, E. M. Choi, S. Y. Rhee, and Y. S. Kim, “Methylglyoxal induces oxidative stress and mitochondrial dysfunction in osteoblastic MC3T3-E1 cells,” Free Radical Research, vol. 48, no. 2, pp. 206–217, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. C. M. Sena, P. Matafome, J. Crisóstomo et al., “Methylglyoxal promotes oxidative stress and endothelial dysfunction,” Pharmacological Research, vol. 65, no. 5, pp. 497–506, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Giacco and M. Brownlee, “Oxidative stress and diabetic complications,” Circulation Research, vol. 107, no. 9, pp. 1058–1070, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. J. L. Evans, I. D. Goldfine, B. A. Maddux, and G. M. Grodsky, “Are oxidative stress—activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?” Diabetes, vol. 52, no. 1, pp. 1–8, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Liu, J. Li, W.-J. Li, and C.-M. Wang, “The role of uncoupling proteins in diabetes mellitus,” Journal of Diabetes Research, vol. 2013, Article ID 585897, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Jitrapakdee, A. Wutthisathapornchai, J. C. Wallace, and M. J. MacDonald, “Regulation of insulin secretion: role of mitochondrial signalling,” Diabetologia, vol. 53, no. 6, pp. 1019–1032, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Runchel, A. Matsuzawa, and H. Ichijo, “Mitogen-activated protein kinases in mammalian oxidative stress responses,” Antioxidants & Redox Signaling, vol. 15, no. 1, pp. 205–218, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Kaneto, T.-A. Matsuoka, Y. Nakatani et al., “Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes,” Journal of Molecular Medicine, vol. 83, no. 6, pp. 429–439, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. X. Jia and L. Wu, “Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats,” Molecular and Cellular Biochemistry, vol. 306, no. 1-2, pp. 133–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Dhar, I. Dhar, B. Jiang, K. M. Desai, and L. Wu, “Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats,” Diabetes, vol. 60, no. 3, pp. 899–908, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Fiory, A. Lombardi, C. Miele, J. Giudicelli, F. Beguinot, and E. Van Obberghen, “Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E,” Diabetologia, vol. 54, no. 11, pp. 2941–2952, 2011. View at Publisher · View at Google Scholar · View at Scopus