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Journal of Diabetes Research
Volume 2016, Article ID 2156273, 17 pages
http://dx.doi.org/10.1155/2016/2156273
Review Article

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

1Ophthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), University of Rovira & Virgili, Reus, Spain
2Department of Ophthalmology, Retina Section, Hospital Universitario de Canarias, Tenerife, Spain
3Department of Ophthalmology, University Hospital Valladolid, Ocular Diabetes Unit of IOBA, Valladolid, Spain

Received 31 May 2016; Revised 29 August 2016; Accepted 6 September 2016

Academic Editor: Goran Petrovski

Copyright © 2016 Pedro Romero-Aroca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [45 citations]

The following is the list of published articles that have cited the current article.

  • Shwu-Jiuan Sheu, and Ying-Yen Lee, “Early response to ranibizumab is associated with 12-month outcome in diabetic macular edema after prior macular laser therapy,” Ophthalmologica, vol. 238, no. 3, pp. 139–146, 2017. View at Publisher · View at Google Scholar
  • Ningshu Liu, Shiying Li, Cheng Sun, Sha Li, Biwei Xu, and Wei Qin, “Efficacy and safety of post-sclera injecting triamcinolone acetonide for diabetic macular edema,” Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology, vol. 35, no. 7, pp. 622–627, 2017. View at Publisher · View at Google Scholar
  • Maurizio Cammalleri, Paola Bagnoli, Filippo Locri, Claudio Pisano, Angelo Mancinelli, Vincenzo Pavone, Stefania Marsili, Massimo Dal Monte, Liliana Lista, Dario Rusciano, and Mario De Rosa, “The urokinase receptor-derived peptide UPARANT recovers dysfunctional electroretinogram and blood-retinal barrier leakage in a rat model of diabetes,” Investigative Ophthalmology and Visual Science, vol. 58, no. 7, pp. 3138–3148, 2017. View at Publisher · View at Google Scholar
  • Wenying Fan, Kang Wang, Khalil Ghasemi Falavarjani, Min Sagong, Akihito Uji, Michael Ip, Charles C. Wykoff, David M. Brown, Jano van Hemert, and SriniVas R. Sadda, “Distribution of Nonperfusion Area on Ultra-Wide Field Fluorescein Angiography in Eyes with Diabetic Macular Edema: DAVE Study,” American Journal of Ophthalmology, 2017. View at Publisher · View at Google Scholar
  • Carl D. Regillo, David G. Callanan, Diana V. Do, Howard F. Fine, Nancy M. Holekamp, Baruch D. Kuppermann, Michael A. Singer, and Rishi P. Singh, “Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel,” Ophthalmic Surgery, Lasers and Imaging Retina, vol. 48, no. 4, pp. 291–301, 2017. View at Publisher · View at Google Scholar
  • Yahiya Y. Syed, “Fluocinolone Acetonide Intravitreal Implant 0.19 mg (ILUVIEN®): A Review in Diabetic Macular Edema,” Drugs, vol. 77, no. 5, pp. 575–583, 2017. View at Publisher · View at Google Scholar
  • M L Shahsuvaryan, “Diabetic retinopathy: in need of multi-dimensional pharmacotherapy,” QJM: An International Journal of Medicine, vol. 111, no. 3, pp. 205–206, 2017. View at Publisher · View at Google Scholar
  • Valentina Sarao, Daniele Veritti, Erica Maurutto, Nicolò Rassu, Enrico Borrelli, Anat Loewenstein, Srinivas Sadda, and Paolo Lanzetta, “Pharmacotherapeutic management of macular edema in diabetic subjects undergoing cataract surgery,” Expert Opinion on Pharmacotherapy, pp. 1–13, 2018. View at Publisher · View at Google Scholar
  • Naoufal Akla, Claire Viallard, Natalija Popovic, Cindy Lora Gil, Przemyslaw Sapieha, and Bruno Larrivée, “BMP9 (Bone Morphogenetic Protein-9)/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 38, no. 8, pp. 1821–1836, 2018. View at Publisher · View at Google Scholar
  • K. Waser, D. Podkowinski, J. Pretzl, A. S. Mursch-Edlmayr, N. Luft, M. Ring, and M. Bolz, “Morphologische retinale Charakteristika von Patienten mit einer Sehbehinderung infolge eines diabetischen Makulaödems,” Der Ophthalmologe, 2018. View at Publisher · View at Google Scholar
  • Christina Y. Weng, David A. Eichenbaum, Charles C. Wykoff, Veeral S. Sheth, and Dilsher S. Dhoot, “When and how to incorporate steroids for persistent diabetic macular edema: A discussion of real-world treatment optimization strategies,” Ophthalmic Surgery Lasers and Imaging Retina, vol. 49, no. 7, pp. S5–S15, 2018. View at Publisher · View at Google Scholar
  • Wei Wang, and Amy Lo, “Diabetic Retinopathy: Pathophysiology and Treatments,” International Journal of Molecular Sciences, vol. 19, no. 6, pp. 1816, 2018. View at Publisher · View at Google Scholar
  • Alfonso Giovannini, Mariacristina Parravano, Federico Ricci, and Francesco Bandello, “Management of diabetic macular edema with intravitreal dexamethasone implants: Expert recommendations using a Delphi-based approach,” European Journal of Ophthalmology, pp. 112067211878123, 2018. View at Publisher · View at Google Scholar
  • Jeremy D. Gale, Brian Berger, Steven Gilbert, Serghei Popa, Marla B. Sultan, Ronald A. Schachar, Douglas Girgenti, and Christelle Perros-Huguet, “A CCR2/5 Inhibitor, PF-04634817, Is Inferior to Monthly Ranibizumab in the Treatment of Diabetic Macular Edema,” Investigative Opthalmology & Visual Science, vol. 59, no. 6, pp. 2659, 2018. View at Publisher · View at Google Scholar
  • Alfredo García-Layana, Marta S. Figueroa, Luis Arias, Alfredo Adán, Francisco Cabrera, Maximino Abraldes, Álvaro Fernández-Vega, Rafael Navarro, Enrique Cervera, Rufino Silva, Felix Armadá, Juan Donate, and José Maria Ruiz-Moreno, “Clinical Decision-Making when Treating Diabetic Macular Edema Patients with Dexamethasone Intravitreal Implants,” Ophthalmologica, vol. 240, no. 2, pp. 61–72, 2018. View at Publisher · View at Google Scholar
  • M.D. Pinazo-Durán, K. Shoaie-Nia, S.M. Sanz-González, J. Raga-Cervera, J.J. García-Medina, M.I. López-Gálvez, D. Galarreta-Mira, L. Duarte, C. Campos-Borges, and V. Zanón-Moreno, “Identification of new candidate genes for retinopathy in type 2 diabetics. Valencia Study on Diabetic Retinopathy (VSDR). Report number 3,” Archivos de la Sociedad Española de Oftalmología (English Edition), 2018. View at Publisher · View at Google Scholar
  • M.D. Pinazo-Durán, K. Shoaie-Nia, S.M. Sanz-González, J. Raga-Cervera, J.J. García-Medina, M.I. López-Gálvez, D. Galarreta-Mira, L. Duarte, C. Campos-Borges, and V. Zanón-Moreno, “Identificación de nuevos genes candidatos para la retinopatía en diabéticos tipo 2. Estudio Valencia sobre Retinopatía Diabética (EVRD). Informe n.° 3,” Archivos de la Sociedad Española de Oftalmología, 2018. View at Publisher · View at Google Scholar
  • Yan-Jie Hao, Ai-Zhi Li, Wen-Wen Hao, and Ming Li, “Macular thickness and macular volume measurements on 1d both preoperatively and postoperatively for diabetic cataract,” International Eye Science, vol. 18, no. 2, pp. 340–342, 2018. View at Publisher · View at Google Scholar
  • Apoorva G. Ayachit, Riccardo Sacconi, Guruprasad S. Ayachit, Shrinivas Joshi, and Giuseppe Querques, “Perifoveal Exudative Vascular Anomalous Complex-Like Lesion as a Complication of Prepapillary Arterial Loops,” Ophthalmic Surgery, Lasers and Imaging Retina, vol. 49, no. 12, pp. 974–978, 2018. View at Publisher · View at Google Scholar
  • Angelo Maria Minnella, Matteo Federici, Valeria Pagliei, Angela Lanza, Gloria Gambini, Carmela Grazia Caputo, Benedetto Falsini, and Aldo Caporossi, “Short-Term Assessment of Intravitreal Dexamethasone Implant Using Enhanced-Depth Image Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients with Retinal Vascular Diseases,” Advances in Therapy, 2018. View at Publisher · View at Google Scholar
  • Andre Maia, Mauricio Maia, Laurentino Biccas Neto, Acacio Muralha Neto, Oswaldo Moura Brasil, Claudio Dalloul, Paulo Mello Filho, Matias Iglicki, Gabriel Andrade, and Eduardo Minelli, “Effectiveness and safety of intravitreal dexamethasone implant (ozurdex) in patients with diabetic macular edema: A real-world experience,” Ophthalmologica, vol. 241, no. 1, pp. 9–16, 2018. View at Publisher · View at Google Scholar
  • Horace Massa, Anindyt M. Nagar, Athanasios Vergados, Panagiotis Dadoukis, Sudeshna Patra, and Georgios D. Panos, “Intravitreal fluocinolone acetonide implant (ILUVIEN®) for diabetic macular oedema: a literature review,” Journal of International Medical Research, pp. 030006051881688, 2018. View at Publisher · View at Google Scholar
  • Elio Striglia, and Massimo Porta, “Farmaci Anti-Vegf Intravitreali E Rischio Cardiovascolare: Un Nuovo Campo Di Interesse Per Il Diabetologo?,” il Diabete, vol. 30, no. N.4,dicembre2018, 2018. View at Publisher · View at Google Scholar
  • Enrique Cervera, Fernando De Andrés-Nogales, Félix Armadá, Luis Arias, Itziar Oyagüez, and Concha Martínez, “Budget impact analysis of dexamethasone intravitreal implant for the treatment of diabetic macular oedema,” Farmacia Hospitalaria, vol. 42, no. 6, pp. 244–250, 2018. View at Publisher · View at Google Scholar
  • Ashley Oake, Charles Preuss, and Yashwant V. Pathak, “Pharmacotherapy of Diabetic Macular Edema and Retinopathy,” Drug Delivery for the Retina and Posterior Segment Disease, pp. 35–50, 2018. View at Publisher · View at Google Scholar
  • Jacqueline Chua, Ai-Ru Chia, Miao Li Chee, Ryan Eyn Kidd Man, Gavin Siew Wei Tan, Ecosse L. Lamoureux, Tien Yin Wong, Mary Foong-Fong Chong, and Leopold Schmetterer, “The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Nicholas A. P. Flinn, and Donald R. Nixon, “Evaluation of contrast sensitivity and other visual function outcomes in diabetic macular edema patients following treatment switch to aflibercept from ranibizumab,” Clinical Ophthalmology, vol. 12, pp. 191–197, 2018. View at Publisher · View at Google Scholar
  • Ying-Yen Lee, Yu-Harn Horng, Huey-Shyan Lin, Wei-Yu Lai, Shwu-Jiuan Sheu, and Chui-Lien Tsen, “Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment,” Clinical Ophthalmology, vol. 12, pp. 1887–1893, 2018. View at Publisher · View at Google Scholar
  • Hyungwoo Lee, Kyung Eun Kang, Hyewon Chung, and Hyung Chan Kim, “Prognostic Factors for Functional and Anatomic Outcomes in Patients with Diabetic Macular Edema Treated with Dexamethasone Implant,” Korean Journal of Ophthalmology, vol. 32, no. 2, pp. 116, 2018. View at Publisher · View at Google Scholar
  • Suleyman Kaynak, Durgul Acan, Eyyup Karahan, and Nilufer Kocak, “Evaluation of systemic risk factors in different optical coherence tomographic patterns of diabetic macular edema,” International Journal of Ophthalmology, vol. 11, no. 7, pp. 1204–1209, 2018. View at Publisher · View at Google Scholar
  • Usha Chakravarthy, Simon R. Taylor, Frank H. Johannes Koch, João Paulo Castro De Sousa, and Clare Bailey, “Changes in intraocular pressure after intravitreal fluocinolone acetonide (ILUVIEN): Real-world experience in three European countries,” British Journal of Ophthalmology, 2018. View at Publisher · View at Google Scholar
  • Kevin Miller, and Jorge A. Fortun, “Diabetic Macular Edema: Current Understanding, Pharmacologic Treatment Options, and Developing Therapies,” Asia-Pacific Journal of Ophthalmology, vol. 7, no. 1, 2018. View at Publisher · View at Google Scholar
  • Dinah Zur, Matias Iglicki, Anna Sala‐Puigdollers, Jay Chhablani, Marco Lupidi, Samantha Fraser‐Bell, Thais Sousa Mendes, Voraporn Chaikitmongkol, Zafer Cebeci, Dolev Dollberg, Catharina Busch, Alessandro Invernizzi, Zohar Habot‐Wilner, and Anat Loewenstein, “Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant,” Acta Ophthalmologica, 2019. View at Publisher · View at Google Scholar
  • Alejandro Fonollosa, Javier Zarranz-Ventura, Alicia Valverde, Erika Becerra, Carolina Bernal-Morales, Salvador Pastor-Idoate, and Miguel Angel Zapata, “Predictive capacity of baseline hyperreflective dots on the intravitreal dexamethasone implant (Ozurdex®) outcomes in diabetic macular edema: a multicenter study,” Graefe's Archive for Clinical and Experimental Ophthalmology, 2019. View at Publisher · View at Google Scholar
  • James F. Young, Andrew Walkden, Amy Stone, and Sajjad Mahmood, “Clinical Effectiveness of Intravitreal Fluocinolone Acetonide (FAc) (ILUVIEN™) in Patients with Diabetic Macular Oedema (DMO) Refractory to Prior Therapy: The Manchester Experience,” Ophthalmology and Therapy, 2019. View at Publisher · View at Google Scholar
  • Grazia Maugeri, Agata Grazia D’Amico, Claudio Bucolo, and Velia D’Agata, “Protective effect of PACAP-38 on retinal pigmented epithelium in an in vitro and in vivo model of diabetic retinopathy through EGFR-dependent mechanism,” Peptides, pp. 170108, 2019. View at Publisher · View at Google Scholar
  • Adrian Hernández Martínez, Ernesto Pereira Delgado, Guillermo Silva Silva, Luis Castellanos Mateos, José Lorente Pascual, Julian Lainez Villa, Paula García Vicente, and Carmen-Victoria Almeida-González, “Early versus late switch: How long should we extend the anti-vascular endothelial growth factor therapy in unresponsive diabetic macular edema patients?,” European Journal of Ophthalmology, pp. 112067211984825, 2019. View at Publisher · View at Google Scholar
  • Maricruz Orduña Ríos, Ramsés Noguez Imm, Nicole Marilú Hernández Godínez, Ana María Bautista Cortes, Dayana Deyanira López Escalante, Wolfgang Liedtke, Atáulfo Martínez Torres, Luis Concha, and Stéphanie Thébault, “TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice,” Plos One, vol. 14, no. 5, pp. e0212158, 2019. View at Publisher · View at Google Scholar
  • Imtiaz M. Nawaz, Sara Rezzola, Anna Cancarini, Andrea Russo, Ciro Costagliola, Francesco Semeraro, and Marco Presta, “Human vitreous in proliferative diabetic retinopathy: Characterization and translational implications,” Progress in Retinal and Eye Research, 2019. View at Publisher · View at Google Scholar
  • Kyoung Lae Kim, Su Young Moon, Hye-Mi Noh, Sung Pyo Park, and Yong-Kyu Kim, “Serum and aqueous humor vitamin D levels in patients with diabetic macular edema,” Graefe's Archive for Clinical and Experimental Ophthalmology, 2019. View at Publisher · View at Google Scholar
  • Justus G. Garweg, Jana Stefanickova, Carel Hoyng, Thomas Schmelter, Tobias Niesen, Olaf Sowade, and Sobha Sivaprasad, “Vision-Related Quality of Life in Patients with Diabetic Macular Edema Treated with Intravitreal Aflibercept: The AQUA Study,” Ophthalmology Retina, 2019. View at Publisher · View at Google Scholar
  • Jean-Francois Korobelnik, Chengxing Lu, Todd A. Katz, Dilsher S. Dhoot, Anat Loewenstein, Jennifer Arnold, and Giovanni Staurenghi, “Effect of Baseline Subretinal Fluid on Treatment Outcomes in VIVID-DME and VISTA-DME Studies,” Ophthalmology Retina, 2019. View at Publisher · View at Google Scholar
  • Selma Alin Somilleda-Ventura, Dulce M. Razo Blanco-Hernández, Surisadai Serafín-Solís, and Virgilio Lima-Gómez, “Should the outcome of focal photocoagulation for center-sparing diabetic macular edema require expanding the definition of center involvement?,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Victor M. Villegas, and Stephen G. Schwartz, “Current and Future Pharmacologic Therapies for Diabetic Retinopathy,” Current Pharmaceutical Design, vol. 24, no. 41, pp. 4903–4910, 2019. View at Publisher · View at Google Scholar
  • Matias Iglicki, Catharina Busch, Dinah Zur, Mali Okada, Miriana Mariussi, Jay Kumar Chhablani, Zafer Cebeci, Samantha Fraser-Bell, Voraporn Chaikitmongkol, Aude Couturier, Ermete Giancipoli, Marco Lupidi, Patricio J. Rodríguez-Valdés, Matus Rehak, Adrian Tien-chin Fung, Michaella Goldstein, and Anat Loewenstein, “Dexamethasone Implant For Diabetic Macular Edema In Naive Compared With Refractory Eyes,” Retina, vol. 39, no. 1, pp. 44–51, 2019. View at Publisher · View at Google Scholar