Review Article

Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory

Table 1

Blood-retina barrier components, types of union, and the molecules located in retinal endothelial junctions.

Type of unionMolecule/component/cell

Tight junctionsClaudins (numbers: 1, 2, 5 and 12)
Endothelial cell-specific adhesion molecule
F11 receptor (jam-1)
Junctional adhesions molecules (numbers: 2 and 3)
Occludin
Zonula occludens (numbers: 1 and 2)

Adherents junctions-Caterin 
VE-Cadherin 
N-Cadherin

Basal membraneBasal membrane

CellsAstrocytes
Endothelial cells
Microglia
Müller cells
Pericytes