Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease
Table 1
Demographic, anthropometric, and biochemical characteristics of coronary artery disease patients included in the study before and after classification according to the median value of RAGE expression at EAT level (Q1 and Q2 groups).
Median
25th–75th percentiles
Range
Q1 (mean ± SD)
Q2 (mean ± SD)
Age (years)
68.00
57.50–71.70
50.00–86.00
68.18 ± 2.99
66.19 ± 2.09
0.67
Weight (Kg)
75.00
65.75–81.50
52.00–135.00
72.88 ± 2.84
84.17 ± 6.12
0.33
BMI (kg/m2)
26.20
23.76–27.90
19.12–41.80
25.14 ± 0.71
28.62 ± 1.44
0.08
Waist (cm)
102.00
93.50–109.05
72.00–144.00
95.94 ± 3.25
109.60 ± 3.61
<0.01
EAT thickness (mm)
7.50
5.78–8.00
3.00–10.00
5.50 ± 0.67
7.58 ± 0.44
<0.05
Fasting glucose (mg/dl)
82.50
77.50–104.50
64.00–177.00
99.24 ± 7.83
91.53 ± 6.59
0.79
Fasting insulin (μU/ml)
7.11
4.17–10.93
3.19–45.06
6.97 ± 0.71
9.07 ± 1.90
0.53
HbA1C (%)
4.68
3.53–5.52
2.79–7.10
4.76 ± 0.36
4.58 ± 0.30
0.71
Total cholesterol (mg/dl)
153.00
138.00–180.30
88.00–261.00
169.80 ± 10.20
146.40 ± 6.81
0.08
HDL cholesterol (mg/dl)
44.00
34.25–49.25
23.00–69.00
44.13 ± 2.50
41.73 ± 3.53
0.58
LDL cholesterol (mg/dl)
83.60
71.50–109.30
17.60–192.00
104.40 ± 9.89
82.57 ± 4.45
0.07
Triglycerides (mg/dl)
107.00
88.50–143.00
64.00–244.00
114.60 ± 9.43
130.10 ± 15.57
0.40
CRP (mg/dl)
0.20
0.10–0.95
0.00–7.90
0.76 ± 0.37
1.23 ± 0.54
0.44
Systolic blood pressure (mmHg)
130.00
120.00–140.00
110.00–150.00
129.10 ± 2.51
131.30 ± 3.26
0.61
Diastolic blood pressure (mmHg)
70.00
70.00–80.00
60.00–80.00
74.55 ± 1.58
83.00 ± 1.49
0.10
%
Q1 (, %)
Q2 (, %)
Smokers
14
42.42
6, 42.85
8, 57.15
0.73
Diabetes mellitus
9
27.27
4, 44.44
5, 55.56
0.70
Hypertension
24
72.73
11, 45.83
13, 54.17
0.44
Dyslipidemia
20
60.61
7, 35.00
13, 65.00
<0.05
Aspirin
19
57.58
6, 31.58
13, 68.42
<0.05
Antidiabetics
6
18.18
3, 50.00
3, 50.00
1
ACEI/ARB
24
72.73
10, 41.67
14, 58.33
0.12
-Blockers
16
48.48
7, 43.75
9, 56.25
0.49
Calcium channel blockers
6
18.18
3, 50.00
3, 50.00
1
Statins
22
66.67
8, 36.36
14, 63.64
<0.05
ACEI: angiotensinogen-converting enzyme inhibitor; ARB: angiotensin receptor blockade; BMI: body mass index; CRP: C-reactive protein; EAT: epicardial adipose tissue; HbA1C: glycated hemoglobin. Data are expressed as median, 25th–75th percentiles and range or number (), and % or mean ± standard deviation (SD).
