An Alteration of Lymphocytes Subpopulations and Immunoglobulins Levels in Patients with Diabetic Foot Ulcers Infected Particularly by Resistant Pathogens
Table 3
The differences in selected parameters of cell-mediated immunity between the study groups.
Evaluated parameters
Patients with DFUs ()
Diabetic controls ()
value
% of total lymphocytes (calculated from blood counts)
23.08 ± 6.2
27.5 ± 6.9
Absolute number of total lymphocytes (×109/L)
1.78 ± 0.61
2.4 ± 0.83
% of CD3+ lymphocytes
75.96 ± 7.64
75.77 ± 6.73
NS
Absolute number of CD3+ lymphocytes (cells/L)
1341 ± 484
1847 ± 669
% of CD4+ lymphocytes
49.33 ± 8.74
47.24 ± 9.78
NS
Absolute number of CD4+ lymphocytes (cells/L)
870 ± 331
1122 ± 382
% of CD8+ lymphocytes
25.4 ± 9.66
27.83 ± 10.84
NS
Absolute number of CD8+ lymphocytes (cells/L)
451 ± 252
712 ± 454
% of CD19+ lymphocytes
10.1 ± 4.84
10.64 ± 4.11
NS
Absolute numbers of CD19+ lymphocytes (cells/L)
188 ± 124
251 ± 111
% of CD4+ naive effector cells
1.43 ± 2.79
3.03 ± 5.45
NS
Absolute number of CD4+ naive effector cells (cells/L)
12.88 ± 27.42
34.72 ± 59.76
% of CD4+ memory effector cells
21.74 ± 9.08
19.44 ± 8.64
NS
Absolute numbers of CD4+ memory effector cells (cells/L)
180 ± 85
220 ± 140
NS
Index of CD4+ naive/memory effector cells
0.09 ± 0.26
0.18 ± 0.38
NS
% of CD4+ naive inactive cells
22.8 ± 12.9
27 ± 13.4
NS
Absolute numbers of CD4+ naive inactive cells (cells/L)
207 ± 154
305 ± 194
% of CD4+ memory inactive cells
54.3 ± 9.8
50.6 ± 10.5
NS
Absolute numbers of CD4+ memory inactive cells (cells/L)
472 ± 194
562 ± 214
Index of CD4+ naive/memory inactive cells
0.47 ± 0.35
0.59 ± 0.37
NS
% of CD8+ naive effector cells
26.4 ± 17.5
24.1 ± 13.3
NS
Absolute number of CD8+ naive effector cells (cells/L)
128 ± 130
189 ± 180
% of CD8+ memory effector cells
31.5 ± 11.2
32.4 ± 12.8
NS
Absolute number of CD8+ memory effector cells (cells/L)
145 ± 106
243 ± 260
Index of CD8+ naive/memory effector cells
1.14 ± 1.28
1.02 ± 1.08
NS
% of CD8+ naive inactive cells
17.9 ± 10.1
21.9 ± 12.1
NS
Absolute number of CD8+ naive inactive cells (cells/L)
73.2 ± 47.4
144.2 ± 131.8
% of CD8+ memory inactive cells
24.2 ± 10.4
21.7 ± 10.7
NS
Absolute number of CD8+ memory inactive cells (cells/L)
105 ± 72
136 ± 79
Index of CD8+ naive/memory inactive cells
0.98 ± 1.02
1.31 ± 1.2
NS
Data are presented as means ± SD; patients with DFUs (diabetic foot ulcers; ); age, sex, and type of diabetes matched diabetic controls (); CD: cluster of differentiation; NS: nonsignificant; value of significance between patients with DFUs and diabetic controls determined using -test or Mann–Whitney test.
