Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity

Table 4

Overall accuracy and ROC analyses of fibrinogen and other markers of inflammation to predict amputation from DFU.

	Cut-off	AUC	Sensitivity (%)	Specificity (%)	NPV (%)	PPV (%)	ACC (%)
Fibrinogen	5.13	0.858 (0.767, 0.950)	80.9	82.6	89.0	78.6	83.6
CRP	28.18	0.812 (0.684, 0.941)	73.7	89.1	87.9	67.6	80.1
WBC	9.87	0.765 (0.643, 0.888)	57.9	84.8	78.2	41.9	70.2
Neutrophil	7.86	0.771 (0.653, 0.888)	52.6	89.1	78.6	50.0	73.8

AUC: area under curve; ACC: accuracy; NPV: negative predictive value; PPV: positive predictive value; WBC: white blood cells; CRP: C-reactive protein.