Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients
Table 1
Characteristics of NGT and T2DM subjects.
Characteristics
NGT ()
T2DM ()
-value
Female [ (%)]
10 (45.5%)
52 (43.3%)
0.750
Age (years)
54.4 ± 2.9
56.3 ± 1.2
0.232
BMI (kg/m2)
26.0 ± 0.5
26.3 ± 0.4
0.340
Systolic BP (mmHg)
128.3 ± 4.0
132.8 ± 1.5
0.186
Diastolic BP (mmHg)
72.1 ± 2.6
76.7 ± 1.1
0.109
FBG (mmol/L)
5.3 ± 0.1
7.8 ± 0.3
<0.001
HbA1c (%)
5.3 ± 0.1
8.6 ± 0.2
<0.001
Fasting insulin (mIU/L)
4.90 (3.2–7.6)
12.0 (7.5–17.8)
<0.001
Fasting C-peptide (ng/mL)
1.5 ± 0.1
1.6 ± 0.1
0.424
Betatrophin (pg/mL)
291.1 ± 37.3
592.1 ± 37.5
<0.001
Irisin (ng/mL)
4.7 ± 0.1
3.4 ± 0.1
<0.001
The data are expressed as the means ± SEM or median (interquartile range) or numbers (%). NGT, normal glucose tolerance; T2DM, type 2 diabetes mellitus; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose.
