Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients

Table 4

Partial correlations between irisin levels and glucose-related variables in T2DM subjects.

Characteristics	Model 1		Model 2		Model 3
	r	P-value	Partial r	P-value	Partial r	P-value
HbA1c	0.062	0.481	0.083	0.383	0.080	0.415
FBG	−0.166	0.053	−0.044	0.646	−0.069	0.486
Fasting insulin	0.031	0.720	0.012	0.899	0.031	0.751
Fasting C-peptide	−0.013	0.886	−0.025	0.796	−0.025	0.803
AUC0.5	−0.091	0.318	−0.071	0.455	−0.067	0.497
AUC1	−0.085	0.349	−0.069	0.470	−0.066	0.505
AUC2	−0.065	0.481	−0.047	0.620	−0.051	0.607
HOMA2-%B	−0.050	0.569	−0.061	0.520	−0.021	0.828
HOMA2-%S	0.243	0.005	0.225	0.017	0.218	0.026
HOMA2-IR	−0.066	0.454	−0.031	0.745	−0.045	0.647

Model 1: unadjusted.
Model 2: adjusted for age, gender, and BMI.
Model 3: adjusted for age, gender, BMI, triglyceride, cholesterol, use of insulin, insulin secretagogues treatment, other antidiabetic medications, and duration of diabetes.