Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

Figure 1

Celastrol exhibited protective effects on livers in diabetic rats. (a) H&E staining (×400) showed hepatic steatosis with lobular inflammation and ballooning of hepatocytes in diabetic rats. Alleviation of the infiltration of inflammatory cells and hepatic steatosis were observed in diabetic rats treated with celastrol. (b) Masson’s staining (×400) showed mild fibrosis changes around perisinusoidal spaces and the portal area in diabetic rats. The degree of fibrosis decreased in celastrol-treated rats. (c) Immunohistochemistry staining of CD68. More Kupffer cells infiltration was detected in diabetic rats and was downregulated by celastrol administration.

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