Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

Figure 2

Celastrol administration downregulated the expressions of the TLR4 and MyD88 in diabetic rats liver. (a-b) Immunohistochemical staining of TLR4 and MyD88 (×400). (c-d) Relative mRNA expression levels of TLR4 and MyD88. (e-f) Relative protein expression levels of TLR4 and MyD88 were analyzed by Western Blotting, and the ratio of TLR4/actin and MyD88/actin was shown. The results are expressed as mean ± SEM, versus NC group; versus DM group; versus CL group; versus CM group.

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