Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

Figure 3

Celastrol administration downregulated NF-κB and p-IκBα expressions in diabetic rats liver. (a) Immunohistochemical staining of NF-κB (×400). (b) Relative mRNA expression levels of NF-κB. (c-d) Relative protein expression levels of p-IκBα and NF-κBp65 were analyzed by Western Blotting, and the ratio of NF-κB/actin and p-IκBα/actin was shown. The results are expressed as mean ± SEM, versus NC group; versus DM group; versus CL group; versus CM group.

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