Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats

Table 3

Physical and biochemical parameters for rats evaluated in this study.

	NC	DM	DM + CL	DM + CM	DM + CH
Glucose (mmol/L)	6.0 ± 0.2	28.2 ± 3.0	25.3 ± 7.1	26.8 ± 6.1	25.0 ± 4.2
Body weight (g)	442.7 ± 43.8	298.6 ± 37.1	309.4 ± 24.2	303.4 ± 29.5	311.3 ± 30.8
Liver index (g/100 g)	2.67 ± 0.23	4.51 ± 0.35	4.42 ± 0.55	4.27 ± 0.44	3.9 ± 0.27
Serum TG (mmol/L)	1.5 ± 1.2	4.4 ± 1.8	4.1 ± 2.1	3.7 ± 2.2	3.5 ± 1.4
Serum TC (mmol/L)	2.2 ± 1.2	6.9 ± 0.9	6.5 ± 2.0	6.4 ± 1.7	6.0 ± 2.1
HDL-C (mmol/L)	0.6 ± 0.1	0.5 ± 0.1	0.5 ± 0.1	0.6 ± 0.1	0.6 ± 0.2
ALT (U/L)	49.7 ± 9.5	55.1 ± 5.1	52.0 ± 9.4	52.7 ± 8.9	50.8 ± 9.1
AST (U/L)	105.1 ± 18.4	109.4 ± 8.4	112.6 ± 9.7	104.3 ± 13.6	104.8 ± 10.5
BUN (mmol/L)	10.9 ± 2.0	10.7 ± 1.6	10.5 ± 1.6	10.9 ± 1.2	9.8 ± 1.8
SCr (μmol/L)	32.8 ± 4.4	31.3 ± 3.3	30.6 ± 3.7	31.4 ± 3.2	30.7 ± 4.1
Liver TG (mg/gprot)	95.8 ± 18.6	412.4 ± 57.8	388.3 ± 38.1	342.4 ± 45.8	228.3 ± 27.5
Liver TC (mg/gprot)	40.3 ± 10.1	134.4 ± 25.1	112.5 ± 20.4	103.2 ± 17.5	88.3 ± 12.4

TG: triglycerides; TC: total cholesterol; HDL-C: high density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; SCr: serum creatinine; NC: normal control; DM: diabetes mellitus; DM + CL: diabetes with low-dose celastrol; DM + CM: diabetes with medium-dose celastrol; DM + CH: diabetes with high-dose celastrol. Data are expressed as mean ± SEM, versus NC group; versus DM group.