Protective Effects of Celastrol on Diabetic Liver Injury via TLR4/MyD88/NF-κB Signaling Pathway in Type 2 Diabetic Rats
Table 3
Physical and biochemical parameters for rats evaluated in this study.
NC
DM
DM + CL
DM + CM
DM + CH
Glucose (mmol/L)
6.0 ± 0.2
28.2 ± 3.0
25.3 ± 7.1
26.8 ± 6.1
25.0 ± 4.2
Body weight (g)
442.7 ± 43.8
298.6 ± 37.1
309.4 ± 24.2
303.4 ± 29.5
311.3 ± 30.8
Liver index (g/100 g)
2.67 ± 0.23
4.51 ± 0.35
4.42 ± 0.55
4.27 ± 0.44
3.9 ± 0.27
Serum TG (mmol/L)
1.5 ± 1.2
4.4 ± 1.8
4.1 ± 2.1
3.7 ± 2.2
3.5 ± 1.4
Serum TC (mmol/L)
2.2 ± 1.2
6.9 ± 0.9
6.5 ± 2.0
6.4 ± 1.7
6.0 ± 2.1
HDL-C (mmol/L)
0.6 ± 0.1
0.5 ± 0.1
0.5 ± 0.1
0.6 ± 0.1
0.6 ± 0.2
ALT (U/L)
49.7 ± 9.5
55.1 ± 5.1
52.0 ± 9.4
52.7 ± 8.9
50.8 ± 9.1
AST (U/L)
105.1 ± 18.4
109.4 ± 8.4
112.6 ± 9.7
104.3 ± 13.6
104.8 ± 10.5
BUN (mmol/L)
10.9 ± 2.0
10.7 ± 1.6
10.5 ± 1.6
10.9 ± 1.2
9.8 ± 1.8
SCr (μmol/L)
32.8 ± 4.4
31.3 ± 3.3
30.6 ± 3.7
31.4 ± 3.2
30.7 ± 4.1
Liver TG (mg/gprot)
95.8 ± 18.6
412.4 ± 57.8
388.3 ± 38.1
342.4 ± 45.8
228.3 ± 27.5
Liver TC (mg/gprot)
40.3 ± 10.1
134.4 ± 25.1
112.5 ± 20.4
103.2 ± 17.5
88.3 ± 12.4
TG: triglycerides; TC: total cholesterol; HDL-C: high density lipoprotein cholesterol; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; SCr: serum creatinine; NC: normal control; DM: diabetes mellitus; DM + CL: diabetes with low-dose celastrol; DM + CM: diabetes with medium-dose celastrol; DM + CH: diabetes with high-dose celastrol. Data are expressed as mean ± SEM, versus NC group; versus DM group.