Review Article

The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review

Table 3

Comparison of altered BCAA level between male and female.

StudyNumberMenFemaleBCAA and related metabolites identifiedRelation between BCAA and IR

Lee et al. [20]68545%55%Valine, leucine, isoleucine, total BCAAPositive,
male > female

Takashina et al. [34]8380%20%Valine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, alanine, arginine, asparagine, α-aminobutyric acid, citrulline, cystine, glutamate, glutamine, glycine, ornithine, proline, serine, taurine, tyrosine, histidinePositive,
male > female

Boulet et al. [32]590%100%Leucine, histidine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, alanine, arginine, citrulline, cystine, glycine, ornithine, proline, serine, taurine, tyrosine, C3Positive (leucine)

Yamada et al. [35]9451%49%Valine, leucine, isoleucine, total BCAA, alanine, tryptophan, phenylalanine, tyrosine, ornithine, glycine, glutamate/glutamine, methionine, lysine, cysteine, aspartic acid, total AA Positive,
male > female

Xie et al. [30]21136%64%Valine, isoleucine, leucine, glutamic acid, tryptophan, tyrosine, carnitine, phenylalanine, alanine, beta-tyrosine, creatinePositive,
male > female

Xie et al. [30]10538%62%Valine, isoleucine, leucine, glutamic acid, tryptophan, tyrosine, carnitine, phenylalanine, alanine, beta-tyrosine, creatinePositive,
male > female

Würtz et al. [28]709848%52%Leucine, isoleucine, valine, glutamine, pyruvate, creatinine, alanine, phenylalanine, phospholipids, fatty acidsPositive,
male > female

Note: IR: insulin resistance; BCAA: branched-chain amino acids; AA: amino acids; study I; study II for validation.