Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

Figure 3

A model of the hIAPP fibril based on crystal structures of small peptide fragments of hIAPP. (a) Primary sequence of human IAPP. Residues color-coded red are found in the first β-strand in the fibril; those colored blue in the second β-strand and the ones located in the partially ordered loop that connects the two stands are colored green. The first seven residues are believed to be outside of the structured core of the fibril and are color-coded black. (b) Top down view of the model with several key residues shown. The N-termini are labeled. (c) View rotated by 90° showing the arrangement of the two stacks as a ribbon diagram.

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