Journal of Diabetes Research / 2016 / Article / Tab 1

Review Article

Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus

Table 1

Molecular targetMechanism of actionReferences

Gap junction inhibitorsIncrease refractory period
Improve conduction

Gap junction openersIncrease conduction velocity and decrease heterogeneity in repolarization or refractoriness [49]

Late sodium channel blockersInhibit afterdepolarizations[83]

Ryanodine receptor stabilizersDecrease heterogeneity in transients and inhibit afterdepolarizations [84]

Antifibrotic agentsReduce cardiac fibrosis[82]

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