The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation

Figure 1

Mechanism of MMPs in chronic wounds. The development of chronic wounds results from delayed inflammation producing high levels of proteinases that destroy the essential elements of wound healing, growth factors, various receptors, and ECM proteins leading to increased MMPs, inflammatory cytokines, and reduced growth factors. The destruction of prohealing factors and ECM also reduces the ability for cells to migrate and proliferate. However as the wound begins to heal through various therapies, there would be increased mitogenic activity, reduced protease activity, and reduction of inflammatory cytokines.