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Journal of Diabetes Research
Volume 2016, Article ID 2902351, 14 pages
Review Article

An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus

1The University of Illinois at Chicago, Chicago, IL 60612, USA
2The Center for Cardiovascular Research, Chicago, IL 60612, USA

Received 5 May 2016; Accepted 27 June 2016

Academic Editor: Zhengyuan Xia

Copyright © 2016 Ahlke Heydemann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only increase. To help in combating the devastating array of phenotypes associated with T2DM a highly reproducible and human disease-similar mouse model is required for researchers. The current options are genetic manipulations to cause T2DM symptoms or diet induced obesity and T2DM symptoms. These methods to model human T2DM have their benefits and their detractions. As far as modeling the majority of T2DM cases, HFD establishes the proper etiological, pathological, and treatment options. A limitation of HFD is that it requires months of feeding to achieve the full spectrum of T2DM symptoms and no standard protocol has been established. This paper will attempt to rectify the last limitation and argue for a standard group of HFD protocols and standard analysis procedures.