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Journal of Diabetes Research
Volume 2016, Article ID 2931985, 9 pages
http://dx.doi.org/10.1155/2016/2931985
Research Article

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

1Unit of Metabolic Diseases and Clinical Dietetics, “Alma Mater Studiorum” University of Bologna, 40138 Bologna, Italy
2Diabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, Italy
3Unit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
4Center for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, Italy
5Diabetes Unit, AUSL Romagna, 48121 Ravenna, Italy
6Biomedical Research Institute August Pi Sunyer (IDIBAPS) and Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), 08036 Barcelona, Spain
7AMD (Italian Association of Clinical Diabetologists), 00192 Rome, Italy

Received 3 November 2015; Revised 25 January 2016; Accepted 29 February 2016

Academic Editor: Daisuke Koya

Copyright © 2016 Gabriele Forlani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. H. Williams, N. A. Shackel, M. D. Gorrell, S. V. McLennan, and S. M. Twigg, “Diabetes and nonalcoholic fatty liver disease: a pathogenic duo,” Endocrine Reviews, vol. 34, no. 1, pp. 84–129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Marchesini, M. Brizi, G. Blanchi et al., “Nonalcoholic fatty liver disease: a feature of the metabolic syndrome,” Diabetes, vol. 50, no. 8, pp. 1844–1850, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Musso, R. Gambino, M. Cassader, and G. Pagano, “Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity,” Annals of Medicine, vol. 43, no. 8, pp. 617–649, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. N. C. Leite, C. A. Villela-Nogueira, V. L. N. Pannain et al., “Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors,” Liver International, vol. 31, no. 5, pp. 700–706, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Hossain, A. Afendy, M. Stepanova et al., “Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease,” Clinical Gastroenterology and Hepatology, vol. 7, no. 11, pp. 1224.e2–1229.e2, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Moscatiello, R. Manini, and G. Marchesini, “Diabetes and liver disease: an ominous association,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 1, pp. 63–70, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Targher and C. D. Byrne, “Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications,” Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 2, pp. 483–495, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Musso, R. Gambino, J. H. Tabibian et al., “Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis,” PLoS Medicine, vol. 11, no. 7, Article ID e1001680, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Targher, C. P. Day, and E. Bonora, “Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease,” The New England Journal of Medicine, vol. 363, no. 14, pp. 1341–1350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. C.-J. Bergqvist, R. Skoien, L. Horsfall, A. D. Clouston, J. R. Jonsson, and E. E. Powell, “Awareness and opinions of non-alcoholic fatty liver disease by hospital specialists,” Internal Medicine Journal, vol. 43, no. 3, pp. 247–253, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. A. L. Fracanzani, L. Valenti, E. Bugianesi et al., “Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes,” Hepatology, vol. 48, no. 3, pp. 792–798, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. A. E. Bohte, J. R. van Werven, S. Bipat, and J. Stoker, “The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis,” European Radiology, vol. 21, no. 1, pp. 87–97, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Marchesini and G. Forlani, “Diabetes and hepatocellular cancer risk: not only a matter of hyperglycemia,” Hepatology, vol. 55, no. 4, pp. 1298–1300, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Bedogni, S. Bellentani, L. Miglioli et al., “The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population,” BMC Gastroenterology, vol. 6, article 33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. C. E. Ruhl and J. E. Everhart, “Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey,” Alimentary Pharmacology and Therapeutics, vol. 41, no. 1, pp. 65–76, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Gastaldelli, M. Kozakova, K. Höjlund et al., “Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population,” Hepatology, vol. 49, no. 5, pp. 1537–1544, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Calori, G. Lattuada, F. Ragogna et al., “Fatty liver index and mortality: the cremona study in the 15th year of follow-up,” Hepatology, vol. 54, no. 1, pp. 145–152, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. Gruppo di Studio Annali AMD, “AMD annals: a model of continuous monitoring and improvement of the quality of diabetes care,” Epidemiologia e Prevenzione, vol. 35, no. 1, pp. 18–26, 2011. View at Google Scholar
  19. A. Nicolucci, M. C. Rossi, A. Arcangeli et al., “Four-year impact of a continuous quality improvement effort implemented by a network of diabetes outpatient clinics: the AMD-Annals initiative,” Diabetic Medicine, vol. 27, no. 9, pp. 1041–1048, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Chalasani, Z. Younossi, J. E. Lavine et al., “The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association,” Hepatology, vol. 55, no. 6, pp. 2005–2023, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Vallet-Pichard, V. Mallet, B. Nalpas et al., “FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and FibroTest,” Hepatology, vol. 46, no. 1, pp. 32–36, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Prati, E. Taioli, A. Zanella et al., “Updated definitions of healthy ranges for serum alanine aminotransferase levels,” Annals of Internal Medicine, vol. 137, no. 1, pp. 1–10, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. A. S. Levey, L. A. Stevens, C. H. Schmid et al., “A new equation to estimate glomerular filtration rate,” Annals of Internal Medicine, vol. 150, no. 9, pp. 604–612, 2009. View at Google Scholar
  24. M. C. E. Rossi, G. Lucisano, M. Comaschi et al., “Quality of diabetes care predicts the development of cardiovascular events: results of the AMD-quasar study,” Diabetes Care, vol. 34, no. 2, pp. 347–352, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. R. J. Wong, M. Aguilar, R. Cheung et al., “Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States,” Gastroenterology, vol. 148, no. 3, pp. 547–555, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Targher, M. Chonchol, G. Zoppini, C. Abaterusso, and E. Bonora, “Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?” Journal of Hepatology, vol. 54, no. 5, pp. 1020–1029, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. H. Ix and K. Sharma, “Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK,” Journal of the American Society of Nephrology, vol. 21, no. 3, pp. 406–412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Li, L. Liu, B. Wang, J. Wang, and D. Chen, “Simple steatosis is a more relevant source of serum inflammatory markers than omental adipose tissue,” Clinics and Research in Hepatology and Gastroenterology, vol. 38, no. 1, pp. 46–54, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Targher, L. Bertolini, S. Rodella et al., “Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients,” Diabetologia, vol. 51, no. 3, pp. 444–450, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Zoppini, U. Fedeli, N. Gennaro, M. Saugo, G. Targher, and E. Bonora, “Mortality from chronic liver diseases in diabetes,” American Journal of Gastroenterology, vol. 109, no. 7, pp. 1020–1025, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. M. C. Rossi, M. R. Cristofaro, S. Gentile et al., “Sex disparities in the quality of diabetes care: biological and cultural factors may play a different role for different outcomes: a cross-sectional observational study from the amd annals initiative,” Diabetes Care, vol. 36, no. 10, pp. 3162–3168, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. V. Soverini, M. Persico, E. Bugianesi et al., “HBV and HCV infection in type 2 diabetes mellitus: a survey in three diabetes units in different Italian areas,” Acta Diabetologica, vol. 48, no. 4, pp. 337–343, 2011. View at Publisher · View at Google Scholar · View at Scopus