The Predictive Effects of Early Pregnancy Lipid Profiles and Fasting Glucose on the Risk of Gestational Diabetes Mellitus Stratified by Body Mass Index

Table 4

The optimal cut-off value for each factor and their combined value for the detection of GDM stratified by p-BMI.

	p-BMI categories; kg/m^2	Cut-off value; mM	AUC	95% CI	Sensitivity	Specificity
Fasting glucose	<18.5	4.77	0.616	0.578, 0.652	54.5	62.7
	18.5–23.9	4.92	0.627	0.611, 0.644	49.5	70.3
	24–27.9	5.00	0.627	0.611, 0.644	52.3	72.8
	≥28	5.05	0.682	0.612, 0.747	64.0	71.3
Cholesterol	<18.5	4.18	0.554	0.517, 0.592	66.3	45.2
	18.5–23.9	4.39	0.533	0.517, 0.550	55.5	51.4
	24–27.9	4.84	0.533	0.517, 0.550	39.6	69.7
	≥28	4.90	0.584	0.511, 0.654	49.3	69.5
Triacylglycerols	<18.5	1.16	0.582	0.544, 0.619	41.6	73.6
	18.5–23.9	0.99	0.552	0.535, 0.568	61.9	46.4
	24–27.9	1.40	0.552	0.535, 0.568	49.4	65.5
	≥28	1.09	0.610	0.537, 0.679	80.3	38.8
TG/HDL-C ratio	<18.5	0.63	0.572	0.535, 0.609	43.8	67.9
	18.5–23.9	0.66	0.554	0.537, 0.571	50.2	58.9
	24–27.9	1.07	0.554	0.537, 0.571	36.3	79.8
	≥28	1.20	0.615	0.543, 0.684	36.0	84.5
LDL-C/HDL-C ratio	<18.5	0.89	0.555	0.517, 0.592	65.2	46.7
	18.5–23.9	0.82	0.536	0.519,0.553	65.2	50.4
	24–27.9	0.52	0.536	0.519, 0.553	33.1	80.4
	≥28	0.57	0.579	0.506, 0.649	57.3	61.2
Combined	<18.5		0.630	0.593, 0.666
	18.5–23.9		0.638	0.622, 0.654
	24–27.9		0.676	0.641, 0.710
	≥28		0.717	0.648, 0.77

p-BMI: prepregnancy body mass index; TG/HDL-C: triglyceride to high-density lipoprotein cholesterol ratio; LDL-C/HDL-C: low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio.