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Journal of Diabetes Research
Volume 2016, Article ID 3102962, 9 pages
http://dx.doi.org/10.1155/2016/3102962
Research Article

Novel Tubular Biomarkers Predict Renal Progression in Type 2 Diabetes Mellitus: A Prospective Cohort Study

Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand

Received 6 May 2016; Revised 20 July 2016; Accepted 23 August 2016

Academic Editor: Monika A. Niewczas

Copyright © 2016 Bancha Satirapoj et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Saran, Y. Li, B. Robinson et al., “Us renal data system 2014 annual data report: epidemiology of kidney disease in the united states,” American Journal of Kidney Diseases, vol. 66, no. 1, supplement 1, pp. S1–305, 2015. View at Publisher · View at Google Scholar
  2. H. H. Parving, B. Oxenbøll, P. A. Svendsen, J. S. Christiansen, and A. R. Andersen, “Early detection of patients at risk of developing diabetic nephropathy. A longitudinal study of urinary albumin excretion,” Acta Endocrinologica, vol. 100, no. 4, pp. 550–555, 1982. View at Google Scholar · View at Scopus
  3. B. Satirapoj and S. G. Adler, “Comprehensive approach to diabetic nephropathy,” Kidney Research and Clinical Practice, vol. 33, no. 3, pp. 121–131, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Fioretto, M. W. Steffes, and M. Mauer, “Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria,” Diabetes, vol. 43, no. 11, pp. 1358–1364, 1994. View at Publisher · View at Google Scholar · View at Scopus
  5. C. E. Hills and P. E. Squires, “The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy,” Cytokine and Growth Factor Reviews, vol. 22, no. 3, pp. 131–139, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Mishra, K. Mori, Q. Ma et al., “Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin,” Journal of the American Society of Nephrology, vol. 15, no. 12, pp. 3073–3082, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. H.-J. Bangstad, I. Seljeflot, T. J. Berg, and K. F. Hanssen, “Renal tubulointerstitial expansion is associated with endothelial dysfunction and inflammation in type 1 diabetes,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 69, no. 1, pp. 138–144, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Jacobsson, H. Lignelid, and U. S. R. Bergerheim, “Transthyretin and cystatin C are catabolized in proximal tubular epithelial cells and the proteins are not useful as markers for renal cell carcinomas,” Histopathology, vol. 26, no. 6, pp. 559–564, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. M. L. Graciano, R. D. C. Cavaglieri, H. Dellê et al., “Intrarenal renin-angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis,” Journal of the American Society of Nephrology, vol. 15, no. 7, pp. 1805–1815, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. S. S. Kim, S. H. Song, I. J. Kim et al., “Clinical implication of urinary tubular markers in the early stage of nephropathy with type 2 diabetic patients,” Diabetes Research and Clinical Practice, vol. 97, no. 2, pp. 251–257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. S. Levey, L. A. Stevens, C. H. Schmid et al., “A new equation to estimate glomerular filtration rate,” Annals of Internal Medicine, vol. 150, no. 9, pp. 604–612, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. A. Eddy and E. G. Neilson, “Chronic kidney disease progression,” Journal of the American Society of Nephrology, vol. 17, no. 11, pp. 2964–2966, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. C. Thomas, W. C. Burns, and M. E. Cooper, “Tubular changes in early diabetic nephropathy,” Advances in Chronic Kidney Disease, vol. 12, no. 2, pp. 177–186, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Satirapoj, C. C. Nast, and S. G. Adler, “Novel insights into the relationship between glomerular pathology and progressive kidney disease,” Advances in Chronic Kidney Disease, vol. 19, no. 2, pp. 93–100, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Mishra, Q. Ma, A. Prada et al., “Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury,” Journal of the American Society of Nephrology, vol. 14, no. 10, pp. 2534–2543, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Togashi and Y. Miyamoto, “Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats,” Experimental and Toxicologic Pathology, vol. 65, no. 5, pp. 615–622, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. W. K. Han, V. Bailly, R. Abichandani, R. Thadhani, and J. V. Bonventre, “Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury,” Kidney International, vol. 62, no. 1, pp. 237–244, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Gociman, A. Rohrwasser, P. Lantelme et al., “Expression of angiotensinogen in proximal tubule as a function of glomerular filtration rate,” Kidney International, vol. 65, no. 6, pp. 2153–2160, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. J. A. M. de Carvalho, E. Tatsch, B. S. Hausen et al., “Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes,” Clinical Biochemistry, vol. 49, no. 3, pp. 232–236, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Bolignano, A. Lacquaniti, G. Coppolino, S. Campo, A. Arena, and M. Buemi, “Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease,” Kidney and Blood Pressure Research, vol. 31, no. 4, pp. 255–258, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Satirapoj, N. Siritaweesuk, and O. Supasyndh, “Urinary angiotensinogen as a potential biomarker of diabetic nephropathy,” Clinical Kidney Journal, vol. 7, no. 4, pp. 354–360, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. X. Rao, M. Wan, C. Qiu, and C. Jiang, “Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus,” Experimental and Therapeutic Medicine, vol. 8, no. 3, pp. 887–892, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. Y.-H. Yang, X.-J. He, S.-R. Chen, L. Wang, E.-M. Li, and L.-Y. Xu, “Changes of serum and urine neutrophil gelatinase-associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study,” Endocrine, vol. 36, no. 1, pp. 45–51, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. S. E. Nielsen, H. Reinhard, D. Zdunek et al., “Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patients,” Diabetes Research and Clinical Practice, vol. 97, no. 1, pp. 71–76, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Nowak, J. Skupien, M. A. Niewczas et al., “Increased plasma kidney injury molecule-1 suggests early progressive renal decline in non-proteinuric patients with type 1 diabetes,” Kidney International, vol. 89, pp. 459–467, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. N. M. Panduru, N. Sandholm, C. Forsblom et al., “Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes,” Diabetes Care, vol. 38, no. 6, pp. 1130–1137, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. S. S. Kim, S. H. Song, I. J. Kim et al., “Urinary cystatin c and tubular proteinuria predict progression of diabetic nephropathy,” Diabetes Care, vol. 36, no. 3, pp. 656–661, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. N. A. Bhavsar, A. Köttgen, J. Coresh, and B. C. Astor, “Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the atherosclerosis risk in communities (ARIC) study,” American Journal of Kidney Diseases, vol. 60, no. 2, pp. 233–240, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. W.-J. Fu, S.-L. Xiong, Y.-G. Fang et al., “Urinary tubular biomarkers in short-term type 2 diabetes mellitus patients: a cross-sectional study,” Endocrine, vol. 41, no. 1, pp. 82–88, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. M. L. Alter, A. Kretschmer, K. Von Websky et al., “Early urinary and plasma biomarkers for experimental diabetic nephropathy,” Clinical Laboratory, vol. 58, no. 7-8, pp. 659–671, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. V. S. Sabbisetti, S. S. Waikar, D. J. Antoine et al., “Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes,” Journal of the American Society of Nephrology, vol. 25, no. 10, pp. 2177–2186, 2014. View at Publisher · View at Google Scholar · View at Scopus