Teneligliptin Decreases Uric Acid Levels by Reducing Xanthine Dehydrogenase Expression in White Adipose Tissue of Male Wistar Rats

Figure 6

Effects of DPP-4 and teneligliptin on Xdh expression in 3T3-L1 adipocytes. Serum-starved 3T3-L1 adipocytes were treated without (□) or with DPP-4 (■; 200 ng/mL) and teneligliptin (1, 5, and 10 μM) for 12 hours. Total RNAs extracted from all cells were used for gene expression analysis of Xdh. Levels of Cph were used for normalization of sample loading. Data are the means ± SEM of 3 independent experiments (1 experiment performed with 6 samples). Data are expressed relative to control values. ; versus DPP-4 treated control cells.